calcipotriol


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Related to calcipotriol: Calcipotriene

calcipotriene

A topical vitamin-D analogue with minimum effects on vitamin-D metabolism, which is FDA-approved for treating mild-to-moderate psoriasis; it is similar in efficacy to topical corticosteroids.

Adverse effects
Rarely, hypercalcaemia.

calcipotriol

A vitamin D-analogue drug used in the treatment of PSORIASIS. A brand name for an external preparation is Dovonex. Formulated with betamethasone it is marketed as Dovobet.
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References in periodicals archive ?
8 sgb v on medicines with the active ingredient combination calcipotriol and betamethasone (atc: D05ax22 - in the dosage form ointment) with possibility of termination at any time in the context of a so-called "open-house model".
After three months of treatment they concluded that all three drugs were efficacious and safe in the treatment of vitiligo, but out of the three drugs, the combination of calcipotriol and betamethasone was superior in efficacy.
Potent corticosteroids and calcipotriol are the most common topical modalities used for psoriasis.
(31), Calcipotriol proved to have a major effect 2004 on the proliferation marker Ki-67 and differentiation marker keratin-10, whereas the effect on T-cell subsets was more selective with major reductions of CD45RO(+) and CD8(+) T cells.
Calcipotriol is a nonsteroidal alternative in the treatment of mild to moderate plaque-type psoriasis and has utility as monotherapy, as well as in combination with topical steroids, and can be used to reduce the frequency or steroidal therapy and associated adverse effects.
Topical calcipotriol/betamethasone dipropionate is a yellow-to-white substance including 50 [micro]g/g calcipotriol and 500 [micro]g/g betamethasone dipropionate.
It was also shown that, calcipotriol, a vitamin D3 analogue, when locally applied on breast cancer skin metastasis, as an ointment, may induce a few partial and minor responses (Bower et al., 1991).
He was treated with topical steroids and calcipotriol, but did not undergo phototherapy or systemic treatment.
The effect of calcipotriol on the expression of human beta defensin-2 and LL-37 in cultured human keratinocytes.
Xu et al., "Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol," British Journal of Dermatology, vol.
Calcipotriol, a synthetic derivative of 1,25, dihydroxy vitamin D3 has been used topically, it acts through vitamin D receptors present on keratinocytes and lymphocytes thus decreasing epidermal proliferation, abnormal keratinization, and angiogenesis.