After three months of treatment they concluded that all three drugs were efficacious and safe in the treatment of vitiligo, but out of the three drugs, the combination of calcipotriol
and betamethasone was superior in efficacy.
Potent corticosteroids and calcipotriol
are the most common topical modalities used for psoriasis.
inhibits proliferation of human keratinocytes by downregulating STAT1 and STAT3 signaling.
proved to have a major effect 2004 on the proliferation marker Ki-67 and differentiation marker keratin-10, whereas the effect on T-cell subsets was more selective with major reductions of CD45RO(+) and CD8(+) T cells.
is a nonsteroidal alternative in the treatment of mild to moderate plaque-type psoriasis and has utility as monotherapy, as well as in combination with topical steroids, and can be used to reduce the frequency or steroidal therapy and associated adverse effects.
Topical calcipotriol/betamethasone dipropionate is a yellow-to-white substance including 50 [micro]g/g calcipotriol
and 500 [micro]g/g betamethasone dipropionate.
It was also shown that, calcipotriol
, a vitamin D3 analogue, when locally applied on breast cancer skin metastasis, as an ointment, may induce a few partial and minor responses (Bower et al., 1991).
He was treated with topical steroids and calcipotriol
, but did not undergo phototherapy or systemic treatment.
The effect of calcipotriol
on the expression of human beta defensin-2 and LL-37 in cultured human keratinocytes.
Xu et al., "Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol
," British Journal of Dermatology, vol.
, a synthetic derivative of 1,25, dihydroxy vitamin D3 has been used topically, it acts through vitamin D receptors present on keratinocytes and lymphocytes thus decreasing epidermal proliferation, abnormal keratinization, and angiogenesis.