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In April, the company cut its revenue growth outlook "mainly driven by the change in calcimimetic drugs." PRICE ACTION: In morning trading, shares of Fresenius Medical Care dropped nearly 17% to $41.46.
Treatment of severe SHPT in CKD is based on control of dietary phosphate intake, gastrointestinal absorption (chelating agents), vitamin D supplementation, and calcimimetic drug intake .
[sup.223]Radium dichloride is a calcimimetic that binds preferentially to a newly formed bone in areas of bone metastases, is the first alpha-emitting radionuclide to be developed for clinical use, and is approved for treatment of castration-resistant prostate cancer and symptomatic bone metastases .
(2014) The odds of using phosphate binders, intravenous vitamin D analogs, and calcimimetic are higher among patients with low-income subsidies (OR = 1.17- 2.38); yet the odds of using oral vitamin D analog is lower among patients with low-income subsidies (OR = 0.70-0.96) Zhang et al.
The recent availability of the calcimimetic agent cinacalcet enables the suppression of parathyroid hormone secretion through activation of the calcium-sensing receptors.
Strontium is a calcimimetic that blocks calcium ion channels.
In an appraisal consultation document, the National Institute for Health and Care Excellence (NICE) has recommended Amgen's (NASDAQ: AMGN) Parsabiv (etelcalcetide) to treat secondary hyperparathyroidism (sHPT), if treatment with a calcimimetic is indicated but cinacalcet is not suitable, and as long as the company provides the drug with the discount agreed in the patient access scheme, Pharma Times reported on Tuesday.
Other reported treatments are calcimimetic agents, bisphosphonates, hyperbaric oxygen, low dose tissue plasminogen activator, and doxycycline .
Mild and asymptomatic hypocalcemia (e.g., in the context of calcimimetic treatment and parathyroidectomy) can be tolerated in order to avoid inappropriate calcium loading in adults [67, 68].
If approved, Parsabiv will be the first calcimimetic agent that can be administered intravenously by a healthcare provider three times a week at the end of a hemodialysis session.
This postrenal transplant hyperparathyroidism could be treated with a calcimimetic or parathyroidectomy, although posttransplant parathyroidectomy may decrease renal transplant function as PTH has a known positive regulatory effect on renal perfusion and glomerular filtration rate [10,11].
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