calcilytic

calcilytic

Of any drug that decreases activation of CALCIUM-SENSING RECEPTORS. Calcilytics increase secretion of parathyroid hormone and can promote its anabolic effects in OSTEOPOROSIS. Compare CALCIMIMETIC.
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Several calcilytic compounds that are antagonists of CaSR have been evaluated as orally active anabolic therapies for postmenopausal osteoporosis, but clinical development of all of them has been abandoned because they lacked tissue selectivity and clinical efficacy [67].
Dal Pra, "Amyloid [beta]-exposed human astrocytes overproduce phospho-tau and overrelease it within exosomes, effects suppressed by calcilytic NPS 2143-further implications for Alzheimer's therapy," Frontiers in Neuroscience, vol.
Calcilytic drugs act as antagonists of calcium-sensing receptors leading to hypocalcemia, thus stimulating pulsatile release of PTH from parathyroid cells.
Whether these observations are true in vivo will determine if specific CaR antagonist (so called calcilytic) could be used therapeutically.
A failed treatment for osteoporosis, a family of drugs called calcilytics, seem to be showing huge promise in reversing the asthma allergic reaction.
One of the researchers, Professor Daniela Riccardi, from Cardiff University School of Biosciences, has said 'If we can prove that calcilytics are safe when administered directly to the lung in people, then in five years we could be in a position to treat patients and potentially stop asthma from happening in the first place.'
Scientists found that the drugs, known as calcilytics, can reverse all symptoms associated with the condition, which affects 300 million people worldwide.
Researchers pumped osteoporosis drugs called calcilytics into the lungs to deactivate the gene and reversed inflammation.
They claim a class of drug known as calcilytics can manipulate CaSR and reverse all asthma symptoms.
on a treatment for hyperparathyroidism (HPT); its calcilytics (for osteoporosis) program with with SmithKline Beecham PLC; its work on excitatory amino acid receptor antagonists with Eli Lilly and Co.; its partnership with Janssen Pharmaceutica Inc.
They claim a class of drugs known as calcilytics can manipulate CaSR and reverse all asthma symptoms.
"Using calcilytics, nebulized directly into the lungs, we show it's possible to deactivate CaSR and prevent symptoms.