Sodium thiosulfate therapy for calcific uremic arteriolopathy
Microscopically, histopathology did not reveal malignancy, but tissue necrosis, widespread luminal compression secondary to vascular calcification, hyperplasia of the tunica intima, and inflammatory cell infiltration--consistent with a diagnosis of calcific uremic arteriolopathy.
Calcific uremic arteriolopathy is not completely understood, with a multifactorial pathogenesis.
Key Words: Calciphylaxis, calcific uremic arteriolopathy
, peritoneal dialysis, chronic kidney disease, end stage renal disease, pressure ulcers.
Calciphylaxis: Calcific uremic arteriolopathy
and the emerging role of sodium thiosulfate.
Cutaneous necrosis by calcific uremic arteriolopathy
Calcific uremic arteriolopathy
has a high mortality, with the chief cause being sepsis following infection of necrotic skin lesions.
A strategy for the treatment of calcific uremic arteriolopathy
(calciphylaxis) employing a combination of therapies.
Key Words: Calcific uremic arteriolopathy
, calciphylaxis, end stage renal disease, chronic kidney disease, hemodialysis, peritoneal dialysis, intraperitoneal sodium thiosulfate.
The mineral content of these lesions consists of calcium and phosphate, so this condition is now referred to as calcific uremic arteriolopathy
Regardless of the etiology of bone disease, skeletal changes that occur in patients with secondary HPT decrease the structural integrity of the bone, leading to a weakened bone matrix and increasing the risk of fracture, hypercalcemia, vascular calcification, and calcific uremic arteriolopathy
(Braun et al.
Calciphylaxis, recently termed calcific uremic arteriolopathy
(CUA), is deleterious because it is painful and life threatening.