Several animal studies have shown that BPA may disturb calcium metabolism by inducing or inhibiting the renal expression of a vitamin D-dependent calcium-binding protein, calbindin-D9k
(CaBP-9k) (Kim et al.
The burst of calcium release from the ER of muscle cells is buffered by the presence of calcium-binding proteins such as calbindin-D9k
Additional evidence for the placental adaption was provided by showing lower expression of the transplacental calcium transfer protein calbindin-D9K
in Igf2 [P0.sup.+/-] at E17 but not at E19 compared to that of wild types .
Jeung, "The classical and a non-classical pathways associated with NF-[kappa]B are involved in estrogen-medicated regulation of Calbindin-D9k
gene in rat pituitary cells," Molecular and Cellular Endocrinology, vol.
The transcellular Ca pathway, which is affected by 1,25-dihydroxyvitamin D (1,25[(OH).sub.2]D), has been proposed to involve Ca entry via TRPV6, intracellular diffusion of Ca by calbindin-D9k
, and basolateral extrusion of Ca by PMCA1b .
Sakuma, "Dietary fructooligosaccharides increase calcium absorption and levels of mucosal calbindin-D9k
in the large intestine of gastrectomized rats," Scandinavian Journal of Gastroenterology, vol.
(CaBP9k) localization and levels of expression in trophoblast cells from human term placenta.
Stimulation of calbindin-D9k
mRNA expression in the rat uterus by octyl-phenol, nonylphenol and bisphenol.
. A vitamin-D-dependent, calcium-binding protein in mineralized tissues.
To confirm whether the reduced E2 levels after BPA treatment resulted in uterine tissue alterations, we examined estrogen-reactive proteins related to cell proliferation (PCNA) and tissue integrity (calbindin-D9k
and collagens) in the uterus.
Tetrabromodiphenyl other (BDE-47) evokes estrogenicity and calbindin-D9k
expression through an estrogen receptor-mediated pathway in the uterus of immature rats.
Studies in rats have shown that subcutaneous injection of p-NP in late pregnancy induces calbindin-D9k
(CaBP-9k) mRNA and protein expression in maternal and neonatal uteri, suggesting its potential transfer through the placenta (Hong et al.