CALB1

(redirected from calbindin 1)

CALB1

A gene on chromosome 8q21.3-q22.1 that encodes calbindin-D28K, a calcium-binding protein of the troponin C superfamily, which contains 4 active calcium-binding domains. Calbindin buffers cytosolic calcium and stimulates membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase; it is synthesised in the brain independent of vitamin D.

Molecular pathology
Cerebral neurones in Huntington disease are
calbindin-D28K depleted.
Mentioned in ?
References in periodicals archive ?
[Source:RefSeq mRNA;Acc:NM_001184752] ENSSSCG00000006125 Sus scrofa calbindin 1, 28kDa (CALB1), mRNA.
Gene name U60145 Fragile X mental retardation 1 X67108 Brain derived neurothrophic factor L20682 Erythroblastosis virus E26 oncogene homolog 1 (avian) M12492 Type IIb subunit of cAMPdependent protein kinase U09401 Tenascin C M31178 Calbindin 1 M85301 Solute carrier family 9, member 4 M35162 Gamma-aminobutyric acid A receptor, delta S39221 N-methyl-D-aspartate receptor U89514 Calpain 9 AA866238 Similar to Acyl carrier protein, mitochondrial precursor U90271 CD152 antigen AB019576 Timeless (Drosophila) homolog Z22607 Bone morphogenetic protein 4 AF083331 Kinesin family member IB A1639073 Similar to Cadherin-related neuronal receptor Acc.
The proteins in Table 1 that do not derive from these previously discussed categories include cytoskeletal proteins (actin [beta], CAPZ [beta] subunit, cofilin, and stathmin 1), transport-related proteins (calbindin 1, fatty acid binding protein 5, transthyretin, and tetranectin), proteolytic proteins (cathepsin D and proteasome subunit [alpha] type 5), and proteins with other or unknown functions (stress-induced phosphoprotein 1, peptidylprolyl isomerase A, oncogene DJ1, TPA:LRRC15, neuropolypeptide h3, esterase D, pyrophosphate phosphorhydrolase, carbonic anhydrase, and calmodulin 3).