calanolide A

calanolide A

A compound derived from a Malaysian tree (Calophyllum lanigerum) that is a natural and unique non-nucleoside reverse transcriptase inhibitor (NNRTI), which appears to have two RTI-binding sites. It was believed to be active against AZT-resistant HIV-1.
References in periodicals archive ?
The lead compound, Calanolide A, is a potent non-nucleotide reverse transcriptase inhibitor anti-HIV agent, and has demonstrated pre-clinical and clinical activity against HIV.
In addition, Calanolide A has demonstrated in vitro activity against Mycobacterium tuberculosis, distinguishing it as the only anti-HIV agent with dual activity against HIV and tuberculosis, the world's number one killer among infectious diseases and the most common infection in HIV patients.
Calanolide A is currently being tested in healthy human volunteers in combination with a marketed HIV protease inhibitor to demonstrate its safety in combination therapy.