cag PAI

cag PAI

A 40-kb genomic fragment present in some Helicobacter pylori, which contains 29 genes that encode parts of a secretory apparatus that translocates a 120-kD CagA protein into the host cell (see Helicobacter pylori). Once inside, the PAI undergoes phosphorylation and binds to SHP-2 tyrosine phosphatase, leading to growth factor-like cellular response and cytokine production by the host cell.
References in periodicals archive ?
pylori contain the gene coding for VacA; however, only those strains that encode the Cag PAI, including CagA, coding for a 128 to 140 kd protein CagA, co-express VacA.
pylori encode Cag PAI, which expresses a type IV secretion system (T4SS).