Smoking (morning urinary cotinine concentration) was positively related to CYP1A2 activity as measured by the caffeine breath test (p < 0.
Liver CYP1A2 activity in humans can be measured in vivo by a noninvasive method, the caffeine breath test (CBT; Kotake et al.
The caffeine breath test and caffeine urinary metabolite ratios in the Michigan cohort exposed to polybrominated biphenyls: a preliminary study.
The effect of age, gender, and sexual maturation on the caffeine breath test.
At the Mohawk Nation at Akwesasne (in New York and in Ontario and Quebec, Canada), 103 adults were interviewed, and they donated blood for serum PCB analysis and underwent the caffeine breath test (CBT), a safe and noninvasive procedure that uses caffeine as a probe for CYP1A2 activity in vivo.
Medical histories were taken to identify those with a history of heart disease, stroke, seizure disorders, uncontrolled hypertension, arrhythmia, hepatitis, jaundice or other types of liver disease, adverse reaction to caffeine, or chemotherapy within the past 5 years that would preclude their participation in the caffeine breath test (CBT).
Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test.