Multiple cafe-au-lait spots
and axillary freckles were observed in the anterior and posterior aspect of the body during the physical examination.
Clinically, NF-1 is characterized by cafe-au-lait spots
, freckling, skin neurofibroma, plexiform neurofibroma, bony defects, Lisch nodules, and tumors of the central nervous system.
Since then, diagnosis has been based on the presence of neurocutaneous stigmata such as cafe-au-lait spots
, axillary, inguinal freckling and cutaneous or subcutaneous neurofibromas and iris hamartomas (Lisch nodules).
Keywords: Cafe-au-lait spots
, Neurofibromatosis, Neurocutaneous, Oligodendroglioma.
NF-1 is characterized by cutaneous and plexiform neurofibromas, skin pigmentation (axillary and inguinal freckling, cafe-au-lait spots
), Lisch nodules, optic glioma or skeletal dysplasias [4, 5].
The bony lesions, involved gonads, and cafe-au-lait spots
are typically all on the same side of the body.
* Cafe-au-lait spots
are well-circumscribed, evenly pigmented, light to dark brown macules and/or patches with an average size of 2 to 5 cm (FIGURE 1B).
On physical examination, there were multiple cafe-au-lait spots
and presence of axillary freckles.
Dermatologic exams for children with NF1 should include evaluation for the presence of cafe-au-lait spots
, neurofibromas, plexiform neurofibromas, and skinfold freckling.
Common abnormalities were growth retardation, cafe-au-lait spots
, hyperpigmentation, microcephaly, finger and thumb deformities Figure 1), Sprengel deformity, and hypogenitalism.
Cutaneous and plexiform fibromas, cafe-au-lait spots
, and optic gliomas are common findings in this hereditary condition.