cadherins


Also found in: Dictionary, Encyclopedia.

cadherins

A family of calcium-dependent adhesion molecules found on the surface of cells. Cadherins are trans-membrane glycoproteins that mediate cell to cell junctions and contribute to the maintenance of cell shape. Cadherins differ in molecular weight at different locations, ranging from 120 to 135Kd.

cadherins

calcium-dependent cell-adhesion molecules.
References in periodicals archive ?
Rapid suppression of activated Racl by cadherins and nectins during de novo cell-cell adhesion.
At present, the role that cadherins play in the pathogenesis of soft tissue sarcomas has not been thoroughly investigated.
In the present study, only 11 (12%) of the sarcomas examined expressed E-cadherin, the major cadherin in epithelial cells.
Cadherins in cancer: implications in invasion and metastasis.
Four products are in the clinical stage of development including Exherin(TM), Adherex' lead cadherin antagonist compound, and STS, a drug that protects against severe hearing loss that is often produced by platinum-based anticancer agents.
Paraffin immunohistochemical stains for cadherins were performed following previously described protocols after steam antigen retrieval.
Adherex' lead cadherin antagonist, Exherin(TM), works by targeting N-cadherin, thereby inhibiting the binding together of the tumor blood vessel cells or the tumor cells themselves, and causing the blood vessels to leak or rupture or the cancer cells to die by apoptosis.
TSX:AHX), a biopharmaceutical company with a broad portfolio of oncology products under development, and Cadherin Biomedical Inc.
Four products are in clinical development including Exherin(TM), Adherex's lead cadherin antagonist compound, and STS, a drug that protects against severe hearing loss that is often produced by platinum-based anticancer agents.
Catenins are multifunctional intracellular proteins that not only bind to cell adhesion molecules called cadherins, but also affect gene expression by interacting with nuclear proteins such as steroid receptors.
This patent provides the company with protection for a broad range of these therapeutic uses including the use of our compounds, alone or in combination with agents that target other cell adhesion molecules including cadherins, integrins, occludins, claudins and JAMs.