cadherins


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cadherins

A family of calcium-dependent adhesion molecules found on the surface of cells. Cadherins are trans-membrane glycoproteins that mediate cell to cell junctions and contribute to the maintenance of cell shape. Cadherins differ in molecular weight at different locations, ranging from 120 to 135Kd.

cadherins

calcium-dependent cell-adhesion molecules.
References in periodicals archive ?
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
Convergence of Wnt, [beta]-catenin, and cadherin pathways.
The observation that cadherins play an important role in the establishment of the epithelial phenotype, cell migration, cell differentiation, and tumor dissemination has stimulated great interest in this family of adhesion molecules.
While the direct link between cadherins and chondrogenesis is not completely understood," Mauck said, "what's known is that if you enhance these interactions early during tissue formation, you can make more cartilage, and, if you block them, you get very poor cartilage formation.
While the direct link between cadherins and chondrogencsis is not completely understood," Mauck said, "what's known is that if you enhance these interactions early during tissue formation, you can make more cartilage, and, if you block them, you get very poor cartilage formation.
Because their extracellular sites have an affinity for calcium, cadherins (Calcium-dependent adhesion) play a central role in cell polarization and adhesion (30).
Rapid suppression of activated Racl by cadherins and nectins during de novo cell-cell adhesion.
The classical cadherins consist of E (epithelial), N (neuronal) and P (placental) cadherin, which are the best studied representatives of this family.
Mueller and colleagues showed that reelin controls the function of cadherins in nerve cells.
Specific topics include cadherins and connexins in pulmonary endothelial function, pulmonary endothelial progenitor cells, oxidant-mediated signaling and injury in pulmonary endothelium, therapeutic strategies to limit pulmonary endothelial cell permeability, genetic insights into endothelial barrier regulation in the acutely inflamed lung, and collagen vascular diseases and pulmonary endothelium.