CDH2

(redirected from cadherin-2)

CDH2

A gene on chromosome 18q11.2 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH2 functions during gastrulation and is required for establishing left-right asymmetry. At certain CNS synapses, presynaptic to postsynaptic adhesion is mediated in part by CDH2; in the hippocampus, it may regulate dendritic spine density.
Mentioned in ?
References in periodicals archive ?
Through collaboration between Harvard University, the Cummings School of Veterinary Medicine at Tufts, the University of Massachusetts Medical School and others, scientists discovered that the canine chromosome 7 location within the neural cadherin-2 gene, or CDH2, confers a high risk of susceptibility to the disorder.
The chromosome 7 location most significantly associated with CCD is located within the neural cadherin-2 gene, CDH2.