CDH17

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CDH17

A gene on chromosome 8q22.1 that encodes cadherin 17, which is a component of the GI tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of medically important peptide-based drugs. Cadherin 17 may also play a role in the morphological organisation of the liver and intestine.
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Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system.
Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine.
Comparison of cadherin-17 expression between primary colorectal adenocarcinomas and their corresponding metastases: the possibility of a diagnostic marker for detecting the primary site of metastatic tumour.
More recently, GATA binding protein 3 (GATA3), arginase 1 (ARG1), trefoil factor (TFF) 1, ankyrin repeat domain 30A (NY-BR-1), sal-like protein 4 (SALL4), special AT-rich sequence-binding protein 2 (SATB2), cadherin-17 (CDH17), and von Hippel-Lindau tumor suppressor (pVHL) have been reported as useful as well.
The third review article comprehensively reviews some diagnostic strategies and algorithms, updates many recently described diagnostic markers such as GATA binding protein 3 (GATA3), placental S100 (S100P), mammary serine protease inhibitor (maspin), von Hippel-Lindau tumor suppressor gene protein (pVHL), paired box gene (PAX) 8, ETS-related gene (ERG), sal-like protein 4 (SALL4), sex-determining region Y box (SOX) 10, arginase-1, napsin A, special AT-rich sequence-binding protein 2 (SATB2), and cadherin-17, and refines the diagnostic IHC panels frequently used in daily practice.
In contrast, cadherin-17 is a positive marker for both lower and upper gastrointestinal adenocarcinomas and neuroendocrine neoplasms.
Cadherin-17 (CDH17), also known as Li-cadherin (liverintestine cadherin), is a member of the cadherin superfamily and is a calcium-dependent transmembrane glycoprotein.
Hematoxylin-eosin stain (A); loss of expression of MLH1 (B); positive for cadherin-17 (C), SATB-2 (D), TFF3 (E), and MUC4 (F) (original magnifications X400).
Hematoxylin-eosin stain (A), strongly positive for cadherin-17 (B) and SATB-2 (C) and weakly positive for CDX2 (D).
Cadherin-17 membranous staining of adenocarcinoma of the colon (A), esophagus (B), pancreas (C), lung (D), endocervix (E), and endometrium (F) (original magnifications X400).