Those experiments were focused on cell-cell and cell-matrix interactions during the formation of the lining and the involvement of Cadherin-11 (Kiener et al., 2006; Lee et al., 2007).
Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro.
Alfandari, "ADAM13 cleavage of cadherin-11 promotes CNC migration independently of the homophilic binding site," Developmental Biology, vol.
Cell invasion placental development HB-EGF, IGF Migration VEGFR2 Limitation of sprouting ADAM13 Cadherin-11 Migration (avoidance of contact inhibition) ADAM15 ?
OB-cadherin (also known as cadherin-11
), a cadherin isoform that is expressed in mesoderm-derived tissues, is known to be involved in cancer progression both positively and negatively.
Epigenetic disruption of cadherin-11
in human cancer metastasis.
Adheron has developed a new technology that disrupts immune cell adhesion through Cadherin-11
, a cell surface protein, to develop potential treatments for various inflammatory and autoimmune diseases.
According to the principle of matrixbased biomimetic modification, our team utilized a recombinant protein, which spans fragments 7-10 of fibronectin module III (heterophilic motif) and extracellular domains 12 of cadherin-11
(rFN/Cad-11) (homophilic motif), to modify the interface of collagen type II (Col II) sponges.
Loss of cadherin-11
adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses.
Future analysis of expression of other cadherin molecules, including vascular-endothelial cadherin and mesodermally expressed cadherin-11
, in this group of neoplasms may reveal additional useful diagnostic information.