CDH11

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CDH11

A gene on chromosome 16q21 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH11 is a so-called type-II (atypical) cadherin—which lacks a HAV cell adhesion recognition sequence specific to type-I cadherins—and is expressed in osteoblastic cell lines. It is upregulated during differentiation, suggesting a role during in bone development and maintenance.

Molecular pathology
Defects in CDH11 commonly occur in aneurysmal bone cysts and consist of a translocation t(16;17)(q22;p13) with USP6.
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OB-cadherin (also known as cadherin-11), a cadherin isoform that is expressed in mesoderm-derived tissues, is known to be involved in cancer progression both positively and negatively.
Adheron has developed a new technology that disrupts immune cell adhesion through Cadherin-11, a cell surface protein, to develop potential treatments for various inflammatory and autoimmune diseases.
According to the principle of matrixbased biomimetic modification, our team utilized a recombinant protein, which spans fragments 7-10 of fibronectin module III (heterophilic motif) and extracellular domains 12 of cadherin-11 (rFN/Cad-11) (homophilic motif), to modify the interface of collagen type II (Col II) sponges.
Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses.
Future analysis of expression of other cadherin molecules, including vascular-endothelial cadherin and mesodermally expressed cadherin-11, in this group of neoplasms may reveal additional useful diagnostic information.