cadherin


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cad·her·in

(kad-hēr'-in),
One of a class of integral-membrane glycoproteins that has a role in cell-cell adhesion and is important in morphogenesis and differentiation; E-cadherin is also known as uvomorulin and is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells. All are calcium-binding proteins.
[cell + adhere + -in]

cadherin

(kăd-hîr′ĭn)
n.
Any of a group of proteins that span the plasma membrane of eukaryotic cells and, in the presence of calcium, bind to identical proteins in adjacent cells, thus linking cells together in tissues.

cad·her·in

(kad-hēr'in)
One of a class of integral-membrane glycoproteins that has a role in cell-to-cell adhesion and is important in morphogenesis and differentiation; E-cadherin (also known as uvomorulin) is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells.

cadherin

one of a family of GLYCOPROTEINS that are involved in cell to cell attachment for preserving the integrity of all solid tissues. Cadherins have three major regions: the extracellular region that mediates ADHESION (cadherin to cadherin) for cell to cell binding; the transmembrane region; and the cytoplasmic region that extends into the cell and interacts with CATENINS, which in turn are linked to the ACTIN of the CYTOSKELETON. Loss of cadherin binding correlates with the invasion of CANCER.

Cadherins also effect tissue formation by modifying their binding strength to allow cell sorting and migration.

References in periodicals archive ?
Hazan, "Differential cadherin expression: potential markers for epithelialto mesenchymal transformation during tumor progression," Journal of Mammary Gland Biology and Neoplasia, vol.
(B) The cells were immunostained with anti-E- cadherin, anti-N-cadherin and anti-Fibronectin antibodies, and nuclei were counterstained with DAPI.
(30.) Oas RG, Nanes BA, Esimai CC, Vincent PA, Garcia AJ, Kowalczyk AP p 120-catenin and [beta]-catenin differentially regulate cadherin adhesive function.
In the present study of 60 cases of invasive ductal carcinoma NOS, an attempt was made to evaluate the p53 status by IHC, the HoxD10, and E Cadherin status by PCR and to correlate them with histological grade and other prognostic factors.
Wheeler et al., "Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
Compared with epithelial cells, this change causes a reduction in mesenchymal cell polarization, inducing the cells to acquire motility properties through mechanisms that are not completely understood, and allows the cadherin switch to associate with the invasive phenotype of cells transformed by the EMT (61).
Although primary [beta]-catenin activation seems to be able to indirectly downregulate E-cadherin, by activating Snail, while it is known that Snail, in turn, can also downregulate nephrin [56], in our model, it is more likely that [beta]-catenin activation is secondary to the cell contact impairment and consequent loss of cadherin. However, Wnt-1/[beta]-catenin pathway has been recently highly considered in the podocytopathies as a new important pathogenetic or favoring factor to be taken into account [57, 58].
Collagenase, MCDB 131 medium, minimum essential medium, antibiotic-antimycotic solution, ophenylenediamine dihydrochloride, diaminobenzidine, Tris, glycine, protease inhibitor cocktail, bovine serum albumin (BSA), fetal bovine serum, monoclonal antibodies against CD31, E-selectin, VEGF, MMP 2, MMP 9, VE cadherin, [beta] catenin, and horseradish-peroxidase- (HRP-) conjugated secondary anti-mouse and anti-rabbit antibody were purchased from M/S Sigma-Aldrich Chemicals (St.
Topics include cell adhesion molecules at the Drosophilia neuromuscular junction, synapse formation in the mammalian central nervous system, developmental axonal pruning and synaptic plasticity, cell adhesion molecules in synatopathies, the cadherin superfamily in synapse formation and function, nectins and nectin-like molecules in the nervous system, the Down syndrome cell adhesion molecule, molecular basis of lamina-specific synaptic connections in the retina, cell adhesion molecules of the NCAM family and their roles at synapses, ephrins and eph receptor tyrosine kinases in synapse formation, the role of integrins at synapses, and extracellular matrix molecules in neuromuscular junctions and central nervous system synapses.
The SNPs were located in chromosome 5 (5p14.1) between cadherin 10 (CDH10) and cadherin 9 (CDH9), two genes that encode neuronal cell-adhesion molecules.