cachexia

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cachexia

 [kah-kek´se-ah]
a profound and marked state of constitutional disorder; general ill health and malnutrition. adj. adj cachec´tic.
cachexia hypophysiopri´va symptoms resulting from total loss of pituitary function, including loss of sexual function, bradycardia, hypothermia, apathy, and coma.
malarial cachexia the physical signs resulting from antecedent attacks of severe malaria, including anemia, sallow skin, yellow sclera, splenomegaly, hepatomegaly, and, in children, retardation of growth and puberty.
pituitary cachexia simmonds' disease.

ca·chex·i·a

(kă-kek'sē-ă),
A general weight loss and wasting occurring in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]

cachexia

(kə-kĕk′sē-ə)
n.
Weight loss, wasting of muscle, loss of appetite, and general debility that can occur during a chronic disease.

cachexia

A state of severe weight loss and tissue wasting seconday to underlying disease—e.g., AIDS, terminal cancer, congestive heart failure, COPD, multiple sclerosis, anorexia nervosa, malnutrition, congestive heart failure, tuberculosis, familial amyloid polyneuropathy, mercury poisoning and hormone deficiency.

Clinical findings
Weight loss, muscle atrophy, fatigue, weakness and anorexia.
 
Mechanism
Cachexia is attributed to an interplay of TNF-alpha, interferon gamma and interleukin 6, and proteolysis-inducing factor, which is secreted by cancers.

Management
Corticosteroids, progesterone-like agents, selective adrenergic receptor modulators.

cachexia

Clinical medicine A state of severe weight lose and tissue wasting 2º to underlying disease–eg, AIDS, terminal CA, anorexia nervosa, or malnutrition. See Tumor necrosis factor.

ca·chex·i·a

(kă-kek'sē-ă)
A general weight loss and wasting occurring in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]

cachexia

A state of severe muscle wasting and weakness occurring in the late stages of serious illnesses such as cancer. The usual condition of bodily decline in those dying after long debilitating illnesses. Cachexia is not due to malnutrition and research findings suggest that an important element in the causation may be selective depletion of the myosin heavy chain in myofibrillary proteins.

Cachexia

A condition of general ill health, malnutrition, undesired weight loss, and physical weakness, often associated with cancer.

ca·chex·i·a

(kă-kek'sē-ă)
General weight loss and wasting in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]