cachexia


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

cachexia

 [kah-kek´se-ah]
a profound and marked state of constitutional disorder; general ill health and malnutrition. adj. adj cachec´tic.
cachexia hypophysiopri´va symptoms resulting from total loss of pituitary function, including loss of sexual function, bradycardia, hypothermia, apathy, and coma.
malarial cachexia the physical signs resulting from antecedent attacks of severe malaria, including anemia, sallow skin, yellow sclera, splenomegaly, hepatomegaly, and, in children, retardation of growth and puberty.
pituitary cachexia simmonds' disease.

ca·chex·i·a

(kă-kek'sē-ă),
A general weight loss and wasting occurring in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]

cachexia

(kə-kĕk′sē-ə)
n.
Weight loss, wasting of muscle, loss of appetite, and general debility that can occur during a chronic disease.

cachexia

A state of severe weight loss and tissue wasting seconday to underlying disease—e.g., AIDS, terminal cancer, congestive heart failure, COPD, multiple sclerosis, anorexia nervosa, malnutrition, congestive heart failure, tuberculosis, familial amyloid polyneuropathy, mercury poisoning and hormone deficiency.

Clinical findings
Weight loss, muscle atrophy, fatigue, weakness and anorexia.
 
Mechanism
Cachexia is attributed to an interplay of TNF-alpha, interferon gamma and interleukin 6, and proteolysis-inducing factor, which is secreted by cancers.

Management
Corticosteroids, progesterone-like agents, selective adrenergic receptor modulators.

cachexia

Clinical medicine A state of severe weight lose and tissue wasting 2º to underlying disease–eg, AIDS, terminal CA, anorexia nervosa, or malnutrition. See Tumor necrosis factor.

ca·chex·i·a

(kă-kek'sē-ă)
A general weight loss and wasting occurring in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]

cachexia

A state of severe muscle wasting and weakness occurring in the late stages of serious illnesses such as cancer. The usual condition of bodily decline in those dying after long debilitating illnesses. Cachexia is not due to malnutrition and research findings suggest that an important element in the causation may be selective depletion of the myosin heavy chain in myofibrillary proteins.

Cachexia

A condition of general ill health, malnutrition, undesired weight loss, and physical weakness, often associated with cancer.

ca·chex·i·a

(kă-kek'sē-ă)
General weight loss and wasting in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]
References in periodicals archive ?
Patients with cachexia had a significantly lower functional capacity and significantly lower handgrip strength than those without cachexia."The disability caused by stroke is usually attributed to brain damage, with little attention paid to the effector organ, which is the skeletal muscle.
The company aims at treating cancer associated wasting through the in-licensing of patent application #15/814284 entitled "Treatment of Cachexia Using Stem Cells and Products Thereof".
MA is a medication often prescribed for anorexia and cachexia, but many prescribers may not recognize its adverse effects including AI and hypogonadism.
studied the potential mechanism in adipocytes using cancer-bearing cachexia mouse models and found that cachectic mouse adipose tissue demonstrated similar morphological changes as to what was observed in atrophic human adipocytes [3, 14].
Cachexia is still underestimated and often untreated [6,7] despite its association with many mechanisms, especially inflammatory, which contribute to the installation of a persistent catabolic status.
Gelatinous marrow transformation (GMT) is a condition of poorly understood pathophysiology observed in cachexia or severe illness, such as sepsis or widespread malignancy.
Pathological inflammation, a hallmark of numerous chronic diseases, can lead to fatal comorbidities, including cachexia [1-4].
As a major complication of malignant tumor, cancer cachexia is defined as a "complex metabolic syndrome" characterized by systemic inflammation, negative protein, and energy balance and an involuntary loss of lean body mass [1-3].
Insulin as a first line drug, is preferred in cases of cachexia or weight loss.
IGC has several patent filings for the indications of pain, medical refractory epilepsy and cachexia using cannabinoids.