KAT5

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KAT5

A gene on chromosome 11q13 that encodes a catalytic subunit of the NuA4 histone acetyltransferase complex (NuA4 HAC) involved in transcriptional activation of genes, principally by acetylating nucleosomal histones H4 and H2A. The NuA4 HAC may be required for activating transcription programmes of oncogene and proto-oncogene mediated growth induction, tumour suppressor-mediated growth arrest/replicative senescence, apoptosis, and DNA repair. Post-translational modifications include sumoylation, phosphorylation, ubiquination and autoacetylation.
References in periodicals archive ?
(70) Galliard's enzyme mentioned above, (58) the cPLA2 reported by Senda et al.
Although calcium is known to be an absolute requirement for the activity of both sPLA2 and cPLA2, its role in the 2 activations is different.
PLA2R1 tiene una cascada de senalizacion intracelular donde se han dilucidado componentes como la p38MAPK (del ingles mitogen-activated protein kinase kinase), e incluso, lejos de ser curioso y no coincidente, las cPLA2. PLA2R1 tambien funciona como un receptor de aclaramiento (del ingles clearance) para las PLA2, en particular parece ser importante esto dada la expresion en macrofago reticulo-endoteliales.
Calcium-dependent phospholipase A2 (cPLA2) and iPLA2 use phosphatidylcholines as substrate to form arachidonic acid, a precursor of several lipid mediators, and lysophosphatidylcholines, a metabolite that can be further degraded to glycerophosphocholine, phosphocholine, or lysophosphatidic acid and choline [22, 23].
Yang et al., "Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability," Brain Research, vol.
Calpactin complexed to annexin II is known to interact with the C-terminus of cytosolic phospholipase A2 and inhibits cPLA2 activity thus reducing inflammatory responses from the release of arachidonic acid [28].
IL-1 increases RANKL expression in osteoblasts by stimulating PG[E.sub.2] production through cytosolic phospholipase A2 (cPLA2) and COX2-dependent mechanisms [31].
5-Lipoxygenase (5-LO), leukotriene (LT), cytosolic phospholipase A2 (cPLA2), arachidonic acid (AA), 5-LO-activatingprotein (FLAP), multidrugresistance protein-1 (MRP1), endothelial cells (ECs), and smooth muscle cells (SMCs).
Rapoport, "Brain lipid metabolism in the cPLA2 knockout mouse," Journal of Lipid Research, vol.
Initially, it was experimentally shown that ceramide stimulates [Ca.sup.2+]-dependent cytosolic phospholipase A2 (cPLA2) and generates cyclooxygenase 2- (Cox2-) mediated prostaglandins in response to TNFa [21].
This leads to the increased expression of inflammatory target proteins such as matrix metalloproteinase-9 (MMP9), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2) and proinflammatory mediators such as the TNF-a, IL-1, and IL-6.