PDE4A

(redirected from cAMP-specific phosphodiesterase)

PDE4A

A gene on chromosome 19p13.2 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing the second messenger cAMP to AMP, thereby having a role in regulating physiological processes.
References in periodicals archive ?
Acrodysostosis type 2 is caused by mutations in cAMP-specific phosphodiesterase 4D (PDE4D).
Recently, genetic defects in cAMP-dependent protein kinase type 1-[alpha] regulatory subunit (PRKAR1A) and cAMP-specific phosphodiesterase 4D (PDE4D) were identified in patients with acrodysostosis by candidate gene analysis (4) and exome sequencing (2,5) respectively.
Aortic rings were incubated in 500 mL of Krebs solution alone or with cAMP-specific phosphodiesterase inhibitor ([10.sup.-7] M rolipram) at 37[degrees]C in a shaker bath.
Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice.
The cAMP-specific phosphodiesterase inhibitor RO-20-1724 induced no metamorphosis and was toxic at the highest concentra-tion of [10.sup.-3] mol [1.sup.-1].
Whereas these compounds inhibit phosphodiesterases in general, RO-20-1724 is a selective inhibitor of the mammalian cAMP-specific phosphodiesterase IV (Thompson, 1993).
Duman, "Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons," Journal of Neurochemistry, vol.
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