PDE4A

(redirected from cAMP-specific phosphodiesterase)

PDE4A

A gene on chromosome 19p13.2 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing the second messenger cAMP to AMP, thereby having a role in regulating physiological processes.
References in periodicals archive ?
Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice.
The cAMP-specific phosphodiesterase inhibitor RO-20-1724 induced no metamorphosis and was toxic at the highest concentra-tion of [10.
Whereas these compounds inhibit phosphodiesterases in general, RO-20-1724 is a selective inhibitor of the mammalian cAMP-specific phosphodiesterase IV (Thompson, 1993).
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