Sanguiin H-6 also decreased the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1), cathepsin K, and c-Src
In addition, c-Src
inhibition can recover cardiac [Na.
Protooncogene tyrosine-protein kinase SRC, also known as protooncogene c-Src
or simply c-Src
, is a nonreceptor tyrosine kinase protein that in humans is encoded by the SRC gene.
Hence, we used the c-Src
inhibitor PP2 to evaluate the involvement of c-Src
in gene transcription stimulated by atrazine and E2 in BG-1 cells (see Supplemental Material, Table S3) and 2008 cells (data not shown).
Mda-9/syntenin was originally cloned in Fisher's laboratory, and was shown in previous studies to interact with another protein, c-Src
, to start a series of chemical reactions that lead to increased metastasis.
Through mechanisms other than antioxidant function: The non-antioxidant mechanism occurs via two key molecular checkpoints: c-Src
N-ACETYL CYSTEINE FOSTERS INACTIVATION AND TRANSFER TO ENDOLYSOSOMES OF C-SRC
Chandan Sen and his group of researchers at The Ohio State University Medical Center showed extremely low level of Tocomin natural full spectrum palm tocotrienol complex prevented glutamate-induced death of neuron cells in mice through the inhibition of c-Src
kinase and 12-lipoxygenase.
The targets included focal adhesion kinase (FAK), Pyk2 (a soluble form of FAK), c-Src
which can phosphorylate FAK, and the MAP kinases ERK1/2, p38 and JNK.
An autophosphorylatable band comigrating with c-Src
is present in the anti-PECAM-1 immunoprecipitate, and c-Src
phosphorylates and binds to a GST fusion protein containing the PECAM-1 cytoplasmic domain.
protein is a 60-kDa nonreceptor tyrosine kinase that is emerging as a potential target for cancer therapy.
expression plays a role in nitric oxide and TNF alpha secretion in macrophages.