Hence, we used the c-Src
inhibitor PP2 to evaluate the involvement of c-Src
in gene transcription stimulated by atrazine and E2 in BG-1 cells (see Supplemental Material, Table S3) and 2008 cells (data not shown).
Mda-9/syntenin was originally cloned in Fisher's laboratory, and was shown in previous studies to interact with another protein, c-Src
, to start a series of chemical reactions that lead to increased metastasis.
Through mechanisms other than antioxidant function: The non-antioxidant mechanism occurs via two key molecular checkpoints: c-Src
N-ACETYL CYSTEINE FOSTERS INACTIVATION AND TRANSFER TO ENDOLYSOSOMES OF C-SRC
The targets included focal adhesion kinase (FAK), Pyk2 (a soluble form of FAK), c-Src
which can phosphorylate FAK, and the MAP kinases ERK1/2, p38 and JNK.
protein is a 60-kDa nonreceptor tyrosine kinase that is emerging as a potential target for cancer therapy.
3] exposure on phosphorylation of Src at tyrosine 416, a specific activation site in the SH1 domain of c-Src
(Dorsam et al.
Working on this prior knowledge, a UCSD team led by Michael Karin speculated that something in cell membranes must be able to differentiate between saturated and unsaturated fats, activating or deactivating Jun kinases and in their new study, the team ultimately identified yet another enzyme, called c-Src
, which resides within a cell membrane.
622 Discovery and characterization of a novel multi-targeted tyrosine kinase inhibitor with activity against c-Ret, PDGFR, c-Kit and c-Src
The protein tyrosine kinases, c-Src
, c-Abl, and Her2/neu, have been implicated convincingly in human cancer and are well validated cell signaling targets for treating cancer.
To test the contributions of each pathway we measured mRNA expression of the genes c-Src
, C/EBP[alpha], NF[kappa]B, and GLUT4 in adipose tissue.
The targets included c-src
which can activate focal adhesion kinase (FAK), PYK2, a soluble form of FAK, and the MAP kinases ERK 1/2, p38 and SAPK/JNK, which can upregulate cytokines that upregulate MMPs.