and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities.
Interestingly, the ability of TKIs to inhibit c-kit activity and signaling may depend on the conformation of c-kit ligand
(SCF) present in the tissues, namely, whether SCF is spliced into a membrane-bound or soluble form.
The riddle of the mast cell: c-kit ligand as missing link?
Development of human mast cells from umblical cord blood cells by recombinant human and murine c-kit ligand. Proc Natl Acad Sci USA 1990; 90: 753-9.
Steel-Dickie mutation encodes a c-kit ligand
lacking transmembrane and cytoplasmic domains.
Normal mast cell proliferation, survival, differentiation, and activation are dependent on binding of stem cell factor or c-KIT ligand
to the KIT receptor.
The study showed that men with two copies of the common version of the c-KIT ligand
(KITLG) gene were 4.5 times more likely develop testicular cancer.
Stem cell factor (c-KIT ligand
) demonstrated strong staining within the epithelium of small and large airways in all cases, while CD25 was positive in mast cells concentrated around airways
Immunohistochemical staining on all previously selected blocks was also done for stem cell factor (SCF; c-KIT ligand
) and CD25 and compared to c-KIT (CD117) staining.
(9, 10) The c-Kit ligand
is an early hematopoietic growth factor and mast cell growth factor.
The protooncogene c-kit and c-kit ligand
in human disease.
The proto-oncogene c-kit and c-kit ligand
in human disease (update on cells and cytokines).