butyrylcholinesterase deficiency

butyrylcholinesterase deficiency

An autosomal recessive MIM 177400 defect in butrylcholinesterase, resulting in suxamethonium/succinylcholine sensitivity, causing prolonged apnea after receiving suxamethonium, which may be exacerbated by liver dysfunction, TB, collagen vascular disease, acute infection, cancer, chronic anaemia, malnutrition, renal failure, pregnancy, rheumatic fever, radiotherapy, chemotherapy, MAOIs, oral contraceptives, ecothiophate iodide, insecticides, neostigmine and pancuronium.
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