butyrylcholinesterase


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BCHE

A gene on chromosome 3q26.1-2 that encodes butyrylcholinesterase, which has a broad substrate spectrum. It contributes to inactivation of the neurotransmitter acetylcholine and can degrade neurotoxic organophosphate esters.
 
Molecular pathology
Mutant alleles at BCHE are responsible for suxamethonium sensitivity.

plas·ma chol·ine·ste·rase

(plaz'mă kō'lin-es'tĕr-ās)
A type of cholinesterase found in plasma.
See also: fluoride number
Synonym(s): butyrylcholinesterase, pseudocholinesterase.
References in periodicals archive ?
Effect of anandamide on acetylcholinesterase, butyrylcholinesterase, paraoxonase-1 and neutrophil elatase in brain of rats subjected to pentylenetetrazole (PTZ)-induced kindling.
Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium.
Ingram et al., "Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer [beta]-amyloid peptide in rodent," Proceedings of the National Academy of Sciences of the United States of America, vol.
An explanation for this finding is caffeine inhibiting the action of butyrylcholinesterase (BuChe) and acetylcholinesterase enzymes (AChE) (1,6,23).
OPs cause cholinergic syndrome, which may result in death due to inhibition of the enzymes acetyl-cholinesterase (AChE) and butyrylcholinesterase [(BuChE) or pseudocholinesterase (PChE)].
Another feature related to AD is the occurrence of dementia, in which the cholinergic neuronal enzymatic activity [i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)] is involved in the optimal impulse transmission at cholinergic synapses.
Adesanya, "Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some selected Nigerian medicinal plants," Brazilian Journal of Pharmacognosy, vol.
The cholinergic system is involved in many physiological functions of the central nervous system, and Ach can be hydrolyzed by acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two independent enzymes in the circulation system.
The isoquinoline alkaloids protopine, allocrytopine and stylopine inhibit human acetylcholinesterase and butyrylcholinesterase (Cahlikova et al.
Some research groups have developed pharmacological therapies through the use of new drugs, (5,6) others have validated immunotherapy methods based on active and passive vaccination procedures, (7,8) and still others have explored the use of proteins that involve destroying cocaine molecules before they have the chance to pass through the blood-brain barrier and penetrate the nervous tissue (figure 1-B), such as the increase in catalytic activity of enzymes such as butyrylcholinesterase (BChE)9-11 and hepatic carboxylesterases (hCE-1 and hCE-2).
Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L.