buspirone hydrochloride

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Related to buspirone hydrochloride: BuSpar

buspirone hydrochloride


Pharmacologic class: Azaspirodecanedione

Therapeutic class: Anxiolytic

Pregnancy risk category B


Unclear. Thought to bind to serotonin and dopamine receptors in CNS, increasing dopamine metabolism and impulse formation. Also thought to inhibit neuronal firing and reduce serotonin turnover.


Tablets: 5 mg, 7.5 mg, 10 mg, 15 mg, 30 mg

Indications and dosages

Anxiety disorders; anxiety symptoms

Adults: 7.5 mg P.O. b.i.d.; increase by 5 mg/day q 2 to 3 days as needed (not to exceed 60 mg/day). Common dosage is 20 to 30 mg/day in divided doses.

Off-label uses

• Parkinsonian syndrome

• Symptomatic relief of depression


• Hypersensitivity to drug

• Severe renal or hepatic impairment

• MAO inhibitor use within past 14 days


Use cautiously in:

• patients receiving concurrent anxi-olytics or psychotropics

• pregnant or breastfeeding patients

• children.


• Give with food to minimize GI upset.

• Know that full benefit of drug therapy may take up to 2 weeks.

Adverse reactions

CNS: dizziness, drowsiness, nervousness, headache, insomnia, weakness, personality changes, numbness, paresthesia, tremor, dream disturbances

CV: chest pain, palpitations, tachycardia, hypertension, hypotension

EENT: blurred vision, conjunctivitis, tinnitus, nasal congestion, sore throat

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dry mouth

GU: dysuria, urinary frequency or hesitancy, menstrual irregularities, menstrual spotting, libido changes

Musculoskeletal: myalgia

Respiratory: chest congestion, hyperventilation, dyspnea

Skin: rash, alopecia, blisters, pruritus, dry skin, easy bruising, edema, flushing, clammy skin, excessive sweating

Other: altered taste or smell, fever


Drug-drug. Erythromycin, itraconazole: increased buspirone blood level

MAO inhibitors: hypertension Trazodone: increased risk of adverse hepatic effects

Drug-food. Grapefruit juice: increased buspirone blood level and effects

Drug-herbs. Hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Monitor mental status closely.

• Assess hepatic and renal function regularly to detect drug toxicity.

Patient teaching

• Instruct patient to take drug with food.

• Advise patient not to use drug to manage everyday stress or tension.

• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Caution patient to avoid alcohol because it increases CNS depression.

• Emphasize importance of keeping follow-up appointments to check progress.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, foods, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

bu·spi·rone hy·dro·chlor·ide

(bū-spī'rōn hī'drō-klōr'īd),
Azaspirodecanedione; antianxiety agent used to manage anxiety disorders or for short-term relief of the symptoms of anxiety.
Farlex Partner Medical Dictionary © Farlex 2012

buspirone hydrochloride

An antianxiety agent that is neither a benzodiazepine nor a barbiturate. It has minimal central nervous system depressant actions, produces minimal sedation, and does not enhance the depressant effects of alcohol and other central nervous system depressants. The drug is used in treating short-term anxiety.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The in-vitro release data were treated by different equations and kinetic models to explain the release kinetics of buspirone hydrochloride from the buccal patches [12].
The sample of buspirone hydrochloride was identified and characterized as per the identification test in official monograph.
Buccal films of buspirone hydrochloride were prepared by solvent casting technique.
In the present study, an attempt was made to design buccal films of buspirone Hydrochloride for treatment/management of anxiety.
Murad, "Solubility analysis of buspirone hydrochloride polymorphs: measurements and prediction," International Journal of Pharmaceutics, vol.