burst-forming unit

burst-forming unit

A small, partially differentiated lymphocyte-like progenitor cell which arises from a pluripotent stem cell, the colony-forming unit for granulocytes(CFU-GEMM), RBCs, megakaryocytes and monocytes in the bone marrow, giving rise to either RBCs (BFU-E) or megakaryocytes (BFU-Meg); these in turn give rise to colony-forming units. The so-called bipolar BFUs have either erythroid or megakaryocytic differentiation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


, burst-forming unit,


A stem cell that produces red blood cell progeny and not blood cells of other lineages.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Colony-forming unit granulocytemacrophage (CFU-GM), colony-forming unit erythroid (CFU-E), burst-forming unit erythroid (BFU-E), and colonyforming unit mix (CFU-Mix) were counted on days 5, 7, 9, and 12, respectively, using a microscope according to the manufacturer's protocol.
Results of colony-forming unit erythroid (CFU-E), granulocyte-macrophage (CFU-GM), burst-forming unit erythroid (BFU-E), and colony-forming unit mix (CFU-Mix) assays of bone marrow of iron overload (Fe) mice and after the administration of deferasirox (DFX) or N-acetyl-L-cysteine (NAC).
[4] Nonstandard abbreviations: HSPC, hematopoietic stem and progenitor cell; MNC, mononuclear cell; rhP/Fc, recombinant human P-selectin/Fc chimera; HBSS, Hanks balanced salt solution; MRE, microrenathane tube; PE, phycoerythrin; sP, P-selectin; CFC, colony-forming cell; BFU-E, burst-forming unit, erythroid; CFU-GM, colony-forming unit, granulocyte-macrophage.
Binding to BFU (burst-forming unit) and CFU (colony-forming unit) receptors of the premature erythrocyte, erythropoietin has a specific effect on the survival and maturation of precursor cells (1).