Medical therapies that were more common with bupropion
overdose included intubation (5% vs.
* Overall, the study found a statistically significant but modest increased likelihood of remission during 12 weeks of augmentation treatment with aripiprazole, compared with switching to bupropion
, an atypical antidepressant, is neutral in terms ofits effect on dopamine levels.
Combination treated group hesperidin (0.5 mg/kg) + bupropion
(5 mg/kg) showed significant decrease in immobility period, as compared to 'hesperidin alone' (1 mg/kg) and 'bupropion
alone' (10 mg/kg) treated groups (Figure 1).
The FDA approved varenicline for smoking cessation in 2006 and approved bupropion
, which also is indicated to treat depression and seasonal affective disorder, in 1997.
Overall, the incidence of neuropsychiatric adverse events was similar in the bupropion
(4.5%), varenicline (4.0%), nicotine patch (3.9%), and the placebo (3.7%) groups.
Despite the presence of a black-box warning about serious neuropsychiatric events in users of bupropion
SR, the task force's review found no significant increase in serious psychiatric events.
The study also found that, compared to the nonabstainers, abstainers using either bupropion
or varenicline experienced lower levels of sadness but, in terms of overall depressive symptoms, the varenicline group fared much better.
* Nortriptyline, which was evaluated in 6 trials, was the only antidepressant besides bupropion
that was superior to placebo.
Cigarette smokers were randomized to 12 weeks of varenicline and bupropion
SR or varenicline and placebo with follow-up through 52 weeks.
is the genetic name for the brand Wellbutrin SR, marketed in the United States by GlaxoSmithKline PLC.
The current study was designed to examine the comparative efficacy of bupropion
for positive and negative symptoms.