buprenorphine


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buprenorphine

 [bu″prĕ-nor´fēn]
a synthetic opioid agonist-antagonist derived from thebaine, used in the form of the hydrochloride salt as an analgesic for moderate to severe pain and as an anesthesia adjunct. Administered sublingually or by intramuscular or intravenous injection.

buprenorphine

(byo͞o′prə-nôr′fēn′)
n.
A semisynthetic opioid drug, C29H41NO4, used usually in its hydrochloride form as an analgesic and, in combination with naloxone, for long-term treatment of addiction to opioids such as heroin.

buprenorphine

A formulation of semi-synthetic opioid which may be superior to methadone in reducing heroin and cocaine abuse/dependence.

Adverse effects
Sedation, constipation.

buprenorphine

Addiction medicine An agent that may be superior to methadone in ↓ heroin and cocaine abuse Side effects Sedation, constipation. Cf Methadone.

buprenorphine

A powerful painkilling drug that binds to the body's opioid receptors. It acts for 6–8 hours. Brand names are Subutex, Temgesic and Transtec.
References in periodicals archive ?
The researchers found that across the five therapeutic classes, the probability a given treatment was on hand was always higher on days when buprenorphine was on hand.
Buprenorphine has been in use in Pakistan as a pain reliever among patients undergoing surgeries but that dose starts from 0.5mg which does not fulfil the addiction treatment criteria.
Several prior studies have examined potential access to buprenorphine waivered physicians.
The guidance outlines ways that companies can more efficiently advance innovations in buprenorphine depot products--from the data needed to support approval, to the specific review pathways that are available to help streamline how sponsors consider their development plans.
Procedures: Buprenorphine hydrochloride (0.3 mg/mL) at each of 3 doses (0.6, 1.2, and 1.8 mg/kg) and saline (0.9% NaCl) solution (control treatment) were administered intramuscularly to birds in a randomized within-subject complete crossover study.
According to the company, the US Food and Drug Administration (FDA) approved Buprenorphine and Naloxone Sublingual Film is indicated for the treatment of opioid dependence under a complete treatment plan that includes counselling and psycho-social support.
Both BUP-XR regimens led to substantial proportions of participants achieving abstinence from opioids, relief of withdrawal symptoms, and control of opioid craving without the need for daily medication adherence or supplemental buprenorphine. Retention was nearly twice as high with BUP-XR compared with placebo.
His first home induction involved a 55-year-old veteran with a history of oxycodone and hydrocodone use who used illicit buprenorphine when he could.
Alone or in combination with naloxone, buprenorphine can be used as in-office-based MAT.
In a flexible-dosing treatment trial, patient baseline characteristics were associated with the buprenorphine dose employed.
This study aims at characterising the safety and efficacy of buprenorphine when used in the paediatric population for the management of acute pain by performing a systematic review and meta-analysis of randomised controlled trials comparing buprenorphine with morphine.