Local Concentrations log [P.sub.(octanol/ anaesthetic utilised water)] (lipid (mg/L) partition coefficient) p[K.sub.a] Prilocaine 4,7 2.1 7 Lignocaine 4,14 2.4 7.9 Ropivacaine 4,6 2.9 8.16 Bupivacaine
4 3.4 8.1 Local Protein Volume of anaesthetic binding distribution (%) (L/kg) Prilocaine 50 0.7-4.4 Lignocaine 70 1-2 Ropivacaine 94 41-59 Bupivacaine
EPOCH 2 was a randomized, placebo- and active-controlled, double-blind, pivotal Phase 3 clinical study evaluating the efficacy and safety of locally administered HTX-011 at 300 mg/9 mg bupivacaine/meloxicam compared to placebo and the standard dose of bupivacaine
solution (75 mg) for postoperative pain control following hernia repair surgery in 418 patients.
Similarly group BP patients received 100 mg Bupivacaine
in 250 ml normal saline into peritoneal cavity.
The team decided to try bupivacaine
because it's inexpensive and has a good duration of action, about 8 hours.
Group A was given 7.5mg and group B was given 10mg of 0.75% Bupivacaine
The overall safety profile of HTX-011, administered locally into the surgical site without a needle, was similar to that of the well-established safety profile of bupivacaine
solution, without evidence of meloxicam-related toxicities.
Conclusion: Fixed dose of 10mg of hyperbaric 0.5% bupivacaine
had similar results to height and weight-adjusted dose of bupivacaine
in spinal anaesthesia for caesarean section.
"Compared with placebo, a liposomal bupivacaine
incisional block at the time of cesarean delivery resulted in similar postoperative pain scores in the first 48 hours postoperatively," the authors write.
Conclusion: 0.5% hyperbaric bupivacaine
was associated with better hemodynamic stability and reduced risk of bradycardia, necessity of rescue ephedrine and nausea/vomiting.
Two patients in group 3 (bupivacaine
) had bradycardia intraoperatively, which was managed with intravenous atropine.
The prospective randomized study was conducted to compare the analgesic efficacy of dilute concentration of bupivacaine
and ropivacaine with fentanyl.
Group R received 20 mL of ropivacaine 0.125% with fentanyl 50 [micro]g, and group B received 20 mL of bupivacaine
0.125% with fentanyl 50 [micro]g.