bullous pemphigoid


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pemphigoid

 [pem´f…………ĭ-goid]
1. resembling pemphigus.
2. any of a group of skin disorders similar to but clearly distinguishable from pemphigus.
benign mucosal pemphigoid a chronic bullous disease of elderly persons, involving primarily the mucous membranes, particularly the conjunctiva and oral mucosa, with scarring.
bullous pemphigoid a usually mild, relatively benign, self-limited blistering skin disease, predominantly affecting elderly persons. IgE antibodies are found at the basement membrane.
localized chronic pemphigoid a form in which bulla formation is confined for many years to a circumscribed region, with scarring but without affecting the mucous membranes.

bul·lous pem·phi·goid

a chronic, generally benign disease, most commonly of old age, characterized by tense nonacantholytic bullae in which serum antibodies are localized to hemidesmosomal components of the epidermal basement membrane, causing detachment of the entire thickness of the epidermis.

bullous pemphigoid

An acquired immunobullous disease characterised by subepidermal bullae formation, linked to deposition of IgG and C3 at the basement membrane in the groin, axilla, scalp, legs and oral cavity.

Increased risk
Immune-mediated diseases—e.g., rheumatoid arthritis, lupus erythematosus, psoriasis, primary biliary cirrhosis, diabetes.
 
DiffDx
Arthropod reactions, bullous amyloidosis, diabetic bullous disease, bullous impetigo, dermatitis herpetiformis, erythema multiforme, epidermolysis bullosa aquisita, linear Ig A disease, pemphigus vulgaris, porphyria cutanea tarda, suction blister.

Pemphigoid variants
Major
• Bullous pemphigoid;
• Mucous membrane (cicatricial) pemphigoid;
• Pemphigus gestationis.

Minor
• Drug induced;
• Lichen planus pemphigoides;
• Paraneoplastic pemphigoid;
• Pemphigoid nodularis;
• Pemphigoid vegetans.

bullous pemphigoid

Dermatology A disease characterized by tense blister–bullae formation on mucocutaneous surfaces, caused by circulating antibodies–usually IgG to the basement membrane of stratified epithelium Clinical BP may be chronic and mild without affecting the general health Management Topical corticosteroids–may require high doses of systemic cortisone. Cf Pemphigus vulgaris.

bul·lous pem·phi·goid

(bul'ŭs pem'fi-goyd)
A chronic, generally benign disease, most commonly of old age, characterized by tense nonacantholytic bullae in which serum antibodies are localized to the epidermal basement membrane, causing detachment of the entire thickness of the epidermis.

bullous pemphigoid

A skin disease of elderly people that features large tense blisters. The condition is caused by an immunological disorder and usually responds well to steroids or immunosuppressive treatment.
References in periodicals archive ?
A skin punch biopsy was performed with the differential diagnoses of bullous pemphigoid, erythema multiforme and bullous drug eruption.
* Of all the various Bullous dermatoses screened, Pemphigus vulgaris was the commonest bullous disorder predisposing to candidosis (40%) followed by Bullous pemphigoid (16.6%), Pemphigus foliaceus (8.3%), Dermatitis Herpetiformis (1.6%) and Pemphigus vegetans (5%).
Bullous pemphigoid is the most common autoimmune blistering disease which usually occurs among elderly patients [10, 11].
Wolf, "Bullous pemphigoid: ethiology, pathogenesis, and inducing factors: facts and controversies," Clinics in Dermatology, vol.
Borradori, "Clinical features and practical diagnosis of bullous pemphigoid," Dermatologic Clinics, vol.
Shimizu, "A case of acquired hemophilia associated with bullous pemphigoid," Skin Research, vol.
A 68-year-old male who had erythrodermic psoriasis with bullous pemphigoid was successfully treated using a combination of methotrexate and compound glycyrrhizin (7).
Furosemide-induced bullous pemphigoid: case report and review literature.
Pathogenesis of PG involves the production of IgG1 antibodies against NC16A domain of carboxyl terminus of Bullous Pemphigoid Antigen 2 (BPAg2), leading to activation of complement, recruitment of eosinophils to the local site and damage of the basement membrane and consequent blistering.
Pure ocular cicatricial pemphigoid is a unique clinical and immunopathological entity distinct from bullous pemphigoid and other subsets identified by antigenic specificity of autoantibodies," Archives of Dermatology, vol.
Besides the diagnosis of SOIJA, in bullous ENL other bullous disorders like pemphigus vulgaris, bullous drug eruption or bullous pemphigoid should be ruled out when there is involvement of oral mucosa and acantholytic cells are found on a Tzanck test.
Q I am a 73-year-old woman who has just been diagnosed with something called bullous pemphigoid. I worked in the geriatrics field before retirement, but had never heard of the condition--can you tell me more about it?