bulky disease

bulky disease

term used for large tumors or lymph nodes; usually more resistant to conventional therapy.
A term for a cancer with a considerable tumour burden—‘bulk’; bulky disease generally has a poorer prognosis independent of the histologic grade; a major priority in oncology is to debulk a tumour to optimise chemo- or radiation therapy

bulky disease

Oncology A term for a CA with a considerable tumor burden–'bulk'; BD generally has a poorer prognosis independent of the histologic grade; a major priority in oncology is to debulk a tumor to optimize chemo- or RT. See Debulking operation.
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This post hoc analysis defined response in patients with relapsed or refractory CLL/SLL, including high-risk subgroups, which were characterized by unmutated IGHV, 17p deletion/TP53 mutation, 11q deletion and bulky disease. Of 158 patients treated with duvelisib, 78% experienced lymphocytosis.
Burkitt lymphoma commonly involves extranodal sites, usually when bulky disease is present.
Patients with limited stage, bulky disease should be treated with six cycles R-CHOP plus 30-40 Gy involved-field radiotherapy rather than six or eight cycles of R-CHOP alone.
Given the uncertainties of frozen section pathologic evaluation in the postchemotherapy setting and bulky disease with what is now considered suboptimal chemotherapy, the authors supported the use of complete bilateral RPLND.
Current FDA approved treatment options for grade I and grade II GI NETs includes somatostatin analogs and everolimus, both of which are cytostatic and of limited use in case of visceral crisis or bulky disease where disease shrinkage is required.
Based on current available data, indications for radiotherapyinclude bulky disease (>7.5 cm), skeletal involvement, and partial response to immunochemotherapy among patients with nonbulky disease [15].
Bulky disease has an impact on outcomes in primary diffuse large B-cell lymphoma of the breast: a retrospective analysis at a single institution.
Patient's demographics, clinical characteristics at presentation like Ann Arbor stage, IPI, presence of bulky disease, baseline and follow-up imaging, biopsy results from residual masses, response to therapy, and survival duration were recorded.
While experimental, for women with bulky disease (greater than 2 cm), neoadjuvant chemotherapy and subsequent trachelectomy has been reported (Gynecol.
"This breath analysis method presents the potential for a cheaper and more reliable diagnostic option for patients found to have bulky disease on a CT scan.
Patients were designated as having bulky disease if the largest single or contiguous tumor mass measured 5 cm or more in diameter.