Antiproliferative activity and new argininyl
bufadienolide esters from the "cururu" toad Rhinella (Bufo) schneideri.
Arenobufagin, a natural
bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
Traditional Chinese Medicine has been widely used for anticancer treatment in China with a long history and many substances possess application prospect, such as
bufadienolide [6, 7].
Arenobufagin, a
bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway.
Hu, "
Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway," Apoptosis, vol.
Mckenzie RA, Franke FP, Dunster PJ (1987) The toxicity to cattle and
bufadienolide content of six Bryophyllum species.
(2009) found that newly laid Bufo marinus (Marine Toad) eggs contained high levels of
bufadienolide (toxin), whereas midstage tadpoles had lower levels and that all stages beyond the egg decreased in toxin diversity.
New insecticidal
bufadienolide, bryophyllin C, from Kalanchoe pinnata.
An endogenous
bufadienolide inhibitor of sodium pump, marinobufagenin, has also been shown to be increased in HF, and its plasma concentrations seem to correlate with severity of disease (65).
Hayashi, "New insecticidal
bufadienolide, bryophyllin C, from Kalanchoe pinnata," Bioscience, Biotechnology and Biochemistry, vol.
Jin et al., "A
bufadienolide derived androgen receptor antagonist with inhibitory activities against prostate cancer cells," Chemico-Biological Interactions, vol.
pinnatum leaf press juice (2.5-10%), a flavonoid fraction (0.1-1 mg/ml), and a
bufadienolide fraction (0.1-40 [micro]g/ml) on detrusor contractility was assessed and compared with controls (polar fraction (0.5-5 mg/ml) and oxybutynin ([10.sup.-8]-[10.sup.-6] M)).
