bufadienolide


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bu·fan·o·lide

(bū-fan'ō-līd),
The fundamental steroid lactone of several vegetable (for example, squill) and animal (for example, toad) venoms or toxins; also found in the form of glycosides in plants (for example, digitalis).

bufadienolide

group of toxic cardiac glycosides found mainly in members of Crassulaceae family, e.g. Cotyledon, Tylecodon, Bryophyllum spp. Found also in skin and skin glands of toads, e.g. Bufo marinus. Those in Cotyledon and Tylecodon are cumulative and produce krimpsiekte (cotyledonosis).
References in periodicals archive ?
Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway.
2009) found that newly laid Bufo marinus (Marine Toad) eggs contained high levels of bufadienolide (toxin), whereas midstage tadpoles had lower levels and that all stages beyond the egg decreased in toxin diversity.
An endogenous bufadienolide inhibitor of sodium pump, marinobufagenin, has also been shown to be increased in HF, and its plasma concentrations seem to correlate with severity of disease (65).
Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that is independent of cholesterol side-chain cleavage.
Preliminary data suggest that the bufadienolide content in the chewable tablets used in the present study was less than 0.
Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum.
2001) reported that all bufadienolides having an orthoacetate and alpha-pyrone moiety showed strong insecticidal activity.
pinnata showed the presence of bufadienolides, terpenoids and flavonoids (Costa et al.