buccal fentanyl

buccal fentanyl

an opioid analgesic.
indications This drug is used to treat breakthrough pain in cancer patients who are taking regularly scheduled doses of another opiate pain medication and who are tolerant to opiates.
contraindications Known intolerance or hypersensitivity to this drug or its components prohibits its use. This drug must not be used in the management of acute or postoperative pain.
adverse effects Adverse effects of this drug include dizziness, delirium, euphoria, lightheadedness, sedation, dysphoria, agitation, anxiety, confusion, headache, depression, bradycardia, hypotension, hypertension, facial flushing, chills, chest pain, dysrhythmias, blurred vision, miosis, nausea, vomiting, diarrhea, cramps, anorexia, constipation, dyspepsia, urinary retention, urgency, dysuria, frequency, oliguria, sweating, pruritus, rash, erythema, papules, asthenia, depressed cough, hypoventilation, dyspnea, hiccups, and apnea. Life-threatening side effects include cardiac arrest, respiratory depression, laryngospasm, and bronchospasm.
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Among the main concerns voiced by panelists was that expanding the approval of buccal fentanyl to what several panelists said was a relatively small patient population would markedly increase the amount of the drug available for diversion, misuse, and abuse.
A warning about the buccal fentanyl formulation was issued in September 2007 (INTERNAL MEDICINE NEWS, Nov.