bryostatin


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bryostatin

Any of a group of 20 different macrolide lactones isolated from a species of bryozoans (moss animals), a phylum of aquatic invertebrates (Bugula neritina), which upregulate protein kinase C (PKC) activity in the short term, and downregulate PKC with prolonged exposure. Bryostatin I inhibits cell growth and angiogenesis, drives cell differentiation and apoptosis and has immunomodulatory activity. While it showed promise as a memory enhancer and in cancer management, it failed as a monotherapy in phase-II clinical trials.
 
Adverse effects
Myalgia.
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References in periodicals archive ?
SUW133 is based on bryostatin 1, a natural compound extracted from a marine animal called Bugula neritina.
Moreover, the top-line data relating to 20 microgram dose of Bryostatin failed to produce results that were statistically significant.
2001) and later that the production of bryostatin serves to protect the host animal larvae from predation (Mathew & Lopanik 2014).
Animal studies have indicated that bryostatin crosses the blood brain barrier.
Using this new research as a guide, one way to tackle the disease may be with bryostatin drugs.
Estos briozoos son de importancia en biotecnologia, puesto que en otras especies del genero se aislo el compuesto bryostatin y tambien algunos antibioticos (Lee et al.
Phase I Study of Bryostatin 1and Fludarabine in Patients with Chronic Lymphocytic Leukemia and Indolent (Non-Hodgkin's).
Bryostatin levels are extremely low in antibiotic-treated B.
ldentification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.