t-value P-value differences deviation Mean FVC(L) measured -0.31 0.18 -5.51 0.00 FVC % predicted -9.90 6.40 -4.89 0.00 FEV1(L) measured -0.24 0.18 -4.16 0.00 FEV1 % predicted -6.30 11.28 -1.77 0.11 FEV1/FVC measured 0.91 8.53 0.34 0.74 FEV1/FVC % predicted 1.10 10.08 0.35 0.74 FEF (25%-75%) (L/s) -0.30 0.38 -2.50 0.03 measured FEF(25%-75%) % predicted -10.10 10.85 -2.95 0.02 PEF(L/s) measured -8.27 25.75 -1.02 0.34 PEF % predicted -9.30 11.87 -2.48 0.04 FVC measured, FVC % predicted, FEF (25%-75%) measured, FEF (25%-75%) % predicted, and PEF % predicted values have increased significantly on bronchodilation
. Table 5: Comparison of prebronchodilator and postbronchodilator values of FEV1 (measured) of the five subjects having obstructive lung disease Pre vs post Paired Std.
If a pathological lung function (improvement of [FEV.sub.1] after bronchodilation
of at least 12%) or ACT (less than 20 points) was ascertained at study visit 2, the patient was definitively registered in the trial.
Vasicine present in the leaves possesses respiratory stimulant activity and induces bronchodilation
as well as relaxation of the tracheal muscle.
Magnesium is involved in such important functions as bronchodilation
and contraction in respiratory tract smooth muscles, mast cell stabilization, neurohumoral mediator release, and mucociliary clearance .
Their major function is not bronchodilation
but rather restoring steroid sensitivity.
Multiple studies have shown that it adds no value over the use of beta-agonists in acute management, including the fact that it provides no further bronchodilation
above that achieved with beta-agonists.
These results may be explained on the basis that NO, which is constitutively produced by the airway epithelium, contributes to maintaining adequate airway function; for example, NO has been implicated in ciliary beating, maintaining bronchodilation
through the formation of s-nitrosothiol compounds, and in bactericidal functions [16, 17].
They are believed to function by binding to the active site of [[beta].sub.2]ARs on airway epithelial and smooth muscle cells, leading to bronchodilation
via activation of adenylyl cyclase, generation of intracellular cAMP, and the associated signaling events .
Light bronchospasm that was triggered by aspiration of a small amount of Lugol's solution was treated with standard bronchodilation
With oxygen support and bronchodilation
treatment, the hypoxemia subsided.
"Aspects of acute stress such as bronchodilation
can actually temporarily mask pollution response."
(27) Despite optimal pharmacological management for bronchodilation
and inflammation control, supplemental oxygen and PLB, most patients with moderate to severe COPD continue to report significant dyspnea during and following exercise.