This drug occupies receptor sites, which prevents leukotrienes from producing their unwanted bronchoconstrictor
effects, airway edema and inflammation.
Although SINGULAIR is effective in improving airway function in asthmatics with documented aspirin sensitivity, it has not been shown to truncate bronchoconstrictor
response to aspirin and other non-steroidal anti-inflammatory drugs in aspirin-sensitive asthmatic patients (see CLINICAL PHARMACOLOGY, Clinical Studies).
Considerations during labor and delivery, when the risk of asthma exacerbations is increased, include avoiding the use of carboprost tromethamine (Hemabate), a very potent bronchoconstrictor
that could cause a "rip-roaring" attack.
2] enhances the bronchoconstrictor
responses to inhaled aeroallergen in specifically sensitized adults with asthma (U.
response to inhaled capsaicin in humans.
The extract contained primarily brevetoxins 2 and 3 but also contained brevenal, a newly identified compound in K brevis having pharmacologic activity antagonistic to brevetoxin-induced neurotoxicity and bronchoconstrictor
activities (Bourdelais et al.
1]-mediated pathway contributing to the bronchoconstrictor
response in vivo (Abraham et al.
This extracellular ATP is rapidly degraded to adenosine, which is a known bronchoconstrictor
These vagal fibers, which mediate neurogenic bronchonconstriction and inflammation, as well as cough, have been shown to be activated by extracellular ATP in animal models in vivo, and aerosolized ATP is a potent bronchoconstrictor
and cough inducer in human subjects, in particular in patients with chronic obstructive airway diseases.
cys-LT are potent proinflammatory mediators [sup] as well as bronchoconstrictors
[sup] in asthma, and the antitussive effect of MONT might be attributable to its anti-inflammatory ability rather than bronchodilation, which was proved previously.
6) Leukotrienes are also potent bronchoconstrictors
and contribute to the NSAID-induced "aspirin asthma" in susceptible patients.
That was the first approval for a leukotriene inhibitor, a class of drugs that blocks the effect of leukotrienes, which are potent, naturally occurring bronchoconstrictors