Methods: Bronchoalveolitis in rats was induced by intratracheal LPS instillation.
Conclusion: BRO exerts significant anti-inflammatory effects and attenuates goblet cell metaplasia in LPS-induced bronchoalveolitis in vivo potentially via interference with 5-LO/LT signaling.
Induction of bronchoalveolitis and animal treatment
Bronchoalveolitis was induced by intratracheal injection of 100 [micro]g LPS from Escherichia coli 0111 :B4 (Sigma-Aldrich, St.
Lesions comprised mild to severe acute necrotizing rhinitis affecting olfactory and respiratory epithelium, focal necrotizing bronchoalveolitis, and marked lymphadenitis (most notably involving the submandibular and retropharyngeal lymph nodes, caudal cervical lymph nodes, and associated peritracheal and periesophageal lymph vessels).
animals with lesion/antigen/ vasculitis ([dagger]) NiV-Bangladesh, System, predominant lesion n = 8 Respiratory Acute rhinitis 7/5/1 Acute bronchoalveolitis 8/8/1 Lymphoid Lymphadenitis 8/8/1 Splenic necrosis 7/7/1 Renal, glomerular necrosis 8/6/0 Hepatic, focal hepatic 8/7/0 necrosis Central nervous Meningitis 0/4/0 Encephalitis 0/7/0 No.