bronchioloalveolar carcinoma


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carcinoma

 [kahr″sĭ-no´mah] (pl. carcinomas, carcino´mata)
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue.
adenocystic carcinoma (adenoid cystic carcinoma) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
alveolar carcinoma bronchioloalveolar carcinoma.
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells, rarely metastatic but locally invasive and aggressive. It usually occurs as small pearly nodules or plaques on the face of an older adult, particularly on a sun-exposed area of someone with fair skin. It has been divided into numerous subtypes on the basis of clinical and histological characteristics.
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements.
bronchioalveolar carcinoma (bronchiolar carcinoma) (bronchioloalveolar carcinoma) (bronchoalveolar carcinoma) a variant type of adenocarcinoma of the lung, with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. Called also alveolar carcinoma or adenocarcinoma and bronchiolar, bronchioloalveolar, or bronchoalveolar adenocarcinoma.
bronchogenic carcinoma any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles, consisting of two layers of cells surrounding a minute lumen. Called also bile duct carcinoma and cholangiocarcinoma.
chorionic carcinoma choriocarcinoma.
colloid carcinoma mucinous carcinoma.
cylindrical cell carcinoma carcinoma in which the cells are cylindrical or nearly so.
embryonal carcinoma a highly malignant germ cell tumor that is a primitive form of carcinoma, probably of primitive embryonal cell derivation; it usually arises in a gonad and may be found either in pure form or as part of a mixed germ cell tumor.
epidermoid carcinoma squamous cell carcinoma.
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs.
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. It is rare in North America and Western Europe but is one of the most common malignancies in parts of sub-Saharan Africa, Southeast Asia, East Asia, and elsewhere. A strong association seems to exist with chronic hepatitis B virus infection.
Hürthle cell carcinoma a malignant Hürthle cell tumor.
carcinoma in si´tu a neoplasm whose tumor cells are confined to the epithelium of origin, without invasion of the basement membrane; the likelihood of subsequent invasive growth is presumed to be high.
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation.
medullary carcinoma that composed mainly of epithelial elements with little or no stroma.
mucinous carcinoma an adenocarcinoma that produces significant amounts of mucin.
nasopharyngeal carcinoma a malignant tumor arising in the epithelial lining of the nasopharynx, occurring at high frequency in people of Chinese descent. The epstein-barr virus has been implicated as a causative agent.
non–small cell carcinoma a general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.
oat cell carcinoma a form of small cell carcinoma in which the cells are round or elongated and slightly larger than lymphocytes; they have scanty cytoplasm and clump poorly.
papillary carcinoma carcinoma in which there are papillary growths that are irregular in nature arising from otherwise normal tissue; it can occur in the thyroid gland, the breast, or the bladder. Called also papillocarcinoma.
renal cell carcinoma carcinoma of the renal parenchyma, composed of tubular cells in varying arrangements; called also clear cell carcinoma.
scirrhous carcinoma carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma. Called also fibrocarcinoma.
carcinoma sim´plex an undifferentiated carcinoma.
small cell carcinoma a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells. Metastasis to the hilum and to mediastinal lymph nodes is common.
spindle cell carcinoma squamous cell carcinoma marked by development of rapidly proliferating spindle cells.
squamous cell carcinoma
1. carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization. Initially local and superficial, the lesion may later invade and metastasize.
2. the form occurring in the skin, usually originating in sun-damaged areas or preexisting lesions.
3. in the lung, one of the most common types of bronchogenic carcinoma, generally forming polypoid or sessile masses that obstruct the airways of the bronchi. It usually occurs in middle-aged individuals with a history of smoking. There is frequent invasion of blood and lymphatic vessels with metastasis to regional lymph nodes and other sites. Called also epidermoid carcinoma.
transitional cell carcinoma a malignant tumor arising from a transitional type of stratified epithelium, usually affecting the urinary bladder.
verrucous carcinoma
1. a variety of squamous cell carcinoma that has a predilection for the buccal mucosa but also affects other oral soft tissue and the larynx. It is slow-growing and somewhat invasive.
2. Buschke-Löwenstein tumor, so called because it is histologically similar to the oral lesion.

al·ve·o·lar cell car·ci·no·ma

a carcinoma, subtype of adenocarcinoma, thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli; involvement may be uniformly diffuse and massive, or nodular, or lobular; microscopically, the neoplastic cells are cuboidal or columnar and form papillary structures; mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells; metastases in regional lymph nodes, and even in more distant sites, are known to occur, but are infrequent.

bronchioloalveolar carcinoma

[brong′kē·ō′lō·al·vē′ə·lər]
the less common variant of the two types of adenocarcinoma of the lung, with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. Also called alveolar adenocarcinoma,alveolar carcinoma,alveolar cell carcinoma, bronchioalveolar adenocarcinoma, bronchioalveolar carcinoma, bronchiolar adenocarcinoma,bronchiolar carcinoma,bronchoalveolar adenocarcinoma,bronchoalveolar carcinoma. See also adenocarcinoma of the lung. Compare bronchogenic adenocarcinoma.

bronchioloalveolar carcinoma

An uncommon carcinoma (±4% of non-small cell lung cancers), which is defined by size (> 5 cm), non-invasive (lepidic) growth along well-preserved alveolar walls and no well-formed glands; those that are invasive are termed adenocarcinoma with a BAC pattern of growth.
 
Epidemiology
More common in those who have never smoked, women and Asians.

Management
Resection, lung transplantation.

Types
• Mucinous—columnar, little atypia, usually worse prognosis because multicentric (28% 5-year survival vs 78% for localised tumours);
• Non-mucinous—hobnail cells, more atypia;
• Mixed.

bronchioloalveolar carcinoma

Oncology A type of adenocarcinoma–representing ±4% of non-small cell lung CAs–that spreads widely throughout the lungs. See Lung cancer.

bron·chi·o·lar car·ci·no·ma

(brong'kē-ō'lăr kahr'si-nō'mă)
A carcinoma, thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli; may be diffuse, nodular, or lobular; the neoplastic cells are cuboidal or columnar and form papillary structures; metastases are infrequent.
Synonym(s): alveolar cell carcinoma, bronchiolar adenocarcinoma, bronchioloalveolar carcinoma, bronchoalveolar carcinoma.
References in periodicals archive ?
To eliminate confusion over the term bronchioloalveolar carcinoma, several authors, (6,10,24-27) including the International Association for the Study of Lung Cancer, American Thoracic Society, and the European Respiratory Society, have suggested eliminating the term bronchioloalveolar carcinoma and replacing it with adenocarcinoma in situ.
A comparison ofsurvival and disease-specific survival in surgically resected, lymph node-positive bronchioloalveolar carcinoma versus nonsmall cell lung cancer: implications for adjuvant therapy.
Evolving concepts in the pathology and ct imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.
5 cm) lung nodules, Marchevsky et al (5) concluded that the distinction between bronchioloalveolar carcinoma (currently adenocarcinoma in situ) and atypical adenomatous hyperplasia was often problematic, and that the diagnostic accuracy was lowest for small (<1.
13,14) Among the tumors formerly termed mucinous bronchioloalveolar carcinoma, the majority of cases are now recognized to have invasive components and are classified as mucinous adenocarcinoma in the proposed new classification.
Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study.
Refactory hypoxemia due to intrapulmonary shunting associated with bronchioloalveolar carcinoma.
While lung transplantation for bronchioloalveolar carcinoma is technically feasible and no longer an absolute contraindication to transplant, recurrence of the original tumor within the donor lungs is common, according to a study appearing in the April 8 issue of The New England Journal of Medicine.
To date the study has enrolled patients with Adenocarcinoma (15), Squamous Cell Carcinoma (three), Bronchioloalveolar Carcinoma (one), and not otherwise specified non-small cell lung cancer (three).
Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.
Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib.
The Pathology and Pathogenesis of Peripheral Lung Adenocarcinoma Including Bronchioloalveolar Carcinoma

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