Three major groups can be identified:
bronchiolitis obliterans with organizing pneumonia (BOOP), usual or nonspecific interstitial pneumonia, and diffuse alveolar damage.
Bronchiolitis obliterans with organizing pneumonia (BOOP) is defined as inflammation of the small airways and surrounding tissue in the lung.
The classic "idiopathic interstitial pneumonia" patterns of usual interstitial pneumonia (UIP), nonspecific interstitial pneumonitis (NSIP),
bronchiolitis obliterans with organizing pneumonia (BOOP), desquamative interstitial pneumonia (DIP), respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) and acute interstitial pneumonitis (AIP) are oftentimes also seen in cases of ILD related to CTD or drug toxicity.
These findings were consistent with bronchiolitis obliterans with organizing pneumonia.
Our patient had a transbronchial biopsy consistent with bronchiolitis obliterans with organizing pneumonia.
A 38-year-old man had undergone allogeneic bone marrow transplantation for multiple myeloma, and his clinical course was complicated by chronic graft-vs-host disease, pulmonary aspergillosis, and
bronchiolitis obliterans with organizing pneumonia (BOOP), which was treated with high-dose steroids.
2) The patient in Rossi's report underwent wedge resection biopsy that revealed histopathologic findings consistent with bronchiolitis obliterans with organizing pneumonia.
This case, in combination with the aforementioned report of topotecan-related bronchiolitis obliterans with organizing pneumonia, adds to a growing understanding of the pulmonary toxicity of topotecan.
Bronchiolitis obliterans with organizing pneumonia (BOOP) is known to be associated with connective tissue disorders.
