A dreaded form of small airways disease in RA is irreversible, constrictive bronchiolitis, which is often diagnosed before a biopsy is performed because of characteristic findings on pulmonary function tests and evidence of bronchiolar
disease, demonstrable by the presence of a mosaic pattern (mosaic perfusion) on high-resolution computed tomography.
Bronchial and bronchiolar
fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans.
One characteristic correlation is that mucinous adenocarcinoma (Figure 2) may be exclusively thyroid transcription factor 1 (TTF1) negative and EGFR-mutation negative, but it may have Ras mutation and expresses CDX2, possibly because of its presumed derivation from bronchiolar
mucinous goblet cells.
Attachment to bronchiolar
epithelium was moderate in seals and scarce in cetaceans, and attachment to alveolar epithelium was scarce in all 4 species.
Follicular cells of the thyroid, areas of the developing brain, type II pneumocytes, and nonciliated bronchiolar
epithelial cells all normally express TTF-1.
LA-exposed SHHF rats developed atypical hyperplastic lesions of bronchiolar
epithelial cell origin at 3 and 6 months.
Findings included diffuse thickening of the interlobular septa, alveolar epithelialization, and polymorphonuclear leukocytes in alveolar and bronchiolar
spaces (Figure 1, panel D).
It is expressed in follicular cells of the thyroid, in areas of the developing brain, in type II pneumocytes, and in nonciliated bronchiolar
Retention in the human alveolar-interstitial region is represented by three compartments, which clear at fast, medium, and slow rates to the lymph nodes and the bronchiolar
region (ICRP 1994).
Immunohistochemical evaluation of lung samples from the badger for antigens of influenza A virus (5) showed rare staining in bronchiolar
epithelial cells (Figure).
SP-B is a marker of lung epithelial cells, and it is expressed primarily by alveolar type II cells (pneumocytes) and bronchiolar
epithelial (Clara) cells.
Influenza virus antigen expression in lung sections was scored for bronchial surface epithelium, bronchial submucosal gland epithelium, bronchiolar
epithelium, alveolar type I pneumocytes, and alveolar type II pneumocytes.