The bronchial challenge test was considered positive when a 15% decrease in [FEV.sub.1] was observed, indicating bronchial hyperresponsiveness
In their paper, authors first illustrated that a trait for an elevated level of serum total IgE was co-inherited with a trait for bronchial hyperresponsiveness
and that a gene governing bronchial hyperresponsiveness
is located near a major locus that regulates serum IgE levels on chromosome 5q.
Namely, exposure to tobacco smoke causes the activation of Th2 lymphocytes [12, 13], an increase in total IgE , allergic sensibilization , and an increase in bronchial hyperresponsiveness
In a Canadian multicenter study of more than 700 patients with a history of physician-diagnosed asthma within the past 5 years, current asthma was ruled out in fully 33% of them on the basis of no deterioration of asthma symptoms, no evidence of reversible airway obstruction, and no bronchial hyperresponsiveness
after all asthma drugs were tapered off (JAMA.
In one study, "Patients with bronchial hyperresponsiveness
to histamine provocation presented significantly more often with ...
Han, "Useful parameters of bronchial hyperresponsiveness
measured with an impulse oscillation technique in preschool children," Journal of Asthma, vol.
Studies showed bacterial diversity and composition of the airway were significantly associated with the severity of airflow obstruction  and bronchial hyperresponsiveness
 and that the abundance of Proteobacteria was associated with worsening asthma control questionnaire (ACQ) scores and positively correlated with Th-17 associated gene expression .
Watson et al., "Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness
," American Journal of Respiratory and Critical Care Medicine, vol.
Subjects with perennial rhinitis were more likely to have current asthma and bronchial hyperresponsiveness
than subjects without perennial rhinitis.
Physical activity and bronchial hyperresponsiveness
: European Community Respiratory Health Survey II.
Effect of inhaled budesonide on bronchial hyperresponsiveness
in adolescents with clinical remission of asthma.
Another explanation for women's greater response to indoor smoke exposure may originate from their bronchial hyperresponsiveness
to air pollution.