A 110-amino acid protein domain which recognises acetylated lysine residues on the N-terminal tails of histone. It is present in over 100 proteins, especially chromatin-associated proteins—e.g., gnc5, peregrin, Snf2, tafii-250.
The fellowship will explore three main modes of reactivity to establish the functionalization of sp3-hydridised carbons with heterocyclic fragments and showcase the value of the synthetic toolbox through the discovery of fragments hits into potent inhibitors of ppis involving the atad2 bromodomain.
Aptose Biosciences announced an exclusive global license agreement that provides OHM Oncology with the rights for the development, manufacture and commercialization of APL-581, as well as related molecules from Aptose's dual bromodomain and extra-terminal domain motif protein and kinase inhibitor program.
com)-- The report provides information on the therapeutic development based on the Bromodomain and Extra-terminal Domain Protein (BET) Inhibitors across 20+ pipeline drugs and 22+ companies active in this field.
The Brd2 gene is a member of the Bromodomain Extra Terminal (BET) family of proteins and is closely related to Brd4, which is important in highly lethal carcinomas in young people, as well as in the replication of Human Immunodeficiency Virus (HIV).
He told Matzuk that he was testing JQ1 as an inhibitor of a member of a family of bromodomain proteins, and he was curious to know whether JQ1 would have an effect on a spermatogenic-specific member of the family called BRDT.