bromocriptine


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Related to bromocriptine: Cabergoline

bromocriptine

 [bro″mo-krip´tēn]
an ergot alkaloid that acts as a dopamine agonist; used as the mesylate salt to suppress prolactin secretion in the treatment of pituitary prolactinomas and of hyperprolactinemia-associated amenorrhea, galactorrhea, infertility, or male hypogonadism. It is also used as an antidyskinetic, usually in conjunction with levodopa, in the treatment of parkinsonism, and is used as a growth hormone suppressant in the treatment of acromegaly. Administered orally.

bromocriptine

(brō′mō-krĭp′tēn)
n.
An ergot alkaloid, C32H40BrN5O5, that is a dopamine antagonist and is used in its mesylate form to treat Parkinson's disease, acromegaly, and excessive prolactin secretion, and to reduce the size of certain pituitary tumors.

bromocriptine

Endocrinology
An ergoline derivative which reduces pituitary prolactin secretion and size of pituitary tumours.
 
Indications
Hyperprolactinemia, pituitary tumours, amenorrhoea, female infertility, hypogonadism, acromegaly, Parkinson’s disease, neuroleptic malignant syndrome, type-2 diabetes.
 
Adverse effects
Orthostatic hypotension, vomiting, vertigo, headaches, upset stomach, coronary vasospasm, pulmonary fibrosis, hepatotoxicity.

Immunology
A dopamine D2-receptor inhibitor which inhibits T-cell-dependent induction of macrophage tumouricidal activity.

bromocriptine

An ERGOT derivative drug with DOPAMINE-like effects. It is used in the treatment of PARKINSON'S DISEASE and ACROMEGALY and given to prevent LACTATION by inhibiting the secretion of the hormone prolactin by the pituitary gland. A brand name is Parlodel.

Bromocriptine

Also known as Parlodel, the main drug used to treat galactorrhea by reducing levels of the hormone prolactin.
Mentioned in: Galactorrhea, Lactation
References in periodicals archive ?
Bromocriptine, a dopamine antagonist that inhibits prolactin secretion prevented the expected deterioration in the size of the left ventricle and systolic function when given in addition to standard heart failure therapy in women with PPCM.
Timed daily administration of bromocriptine to reestablish the daily peak in SCN dopaminergic activity also reverses the VMH and PVN abnormalities described above [30, 37, 46] and improves postprandial insulin resistance (even via its intracerebroventricular administration) [26, 30, 45].
Long-acting injectable bromocriptine does not reduce relapse in alcoholics.
Such an increased PRL was significantly attenuated by treatment with 0.6mg/kg bromocriptine or 6.4 or 12.8 g/kg WEFHG after one month of administration (P < 0.01 versus the model group).
The second review, of 7 trials with a total of 1100 patients, compared bromocriptine plus levodopa with levodopa alone.
Daily treatment of insulin resistant/glucose-intolerant animals with appropriately time-pulsed systemic or intracerebroventricular administration of the dopamine D2 receptor agonist bromocriptine to increase hypothalamic dopaminergic tone improves insulin resistance and glucose intolerance.
European multicentre trial of bromocriptine in cyclical mastalgia.
Effects of the dopamine agonist cabergoline in patients with prolactinoma intolerant or resistant to bromocriptine. Eur J Endocrinol 1996;134:454-456.
Bromocriptine has shown an overall response rate of 75% in two separate double-blind studies.
A retrospective analysis of published cases indicated that the use of bromocriptine and/or dantrolene appeared to hasten clinical response.
Second-line agents include dopamine agonists (pramipexole, ropinirole, and bromocriptine) and monoamine oxidase type B (MAO-B) inhibitors (selegiline, rasagiline) (table (16,17)).
The mainstay for treatment of symptomatic hyperprolactinemia, particularly patient's with anovulation, infertility, or galactorrhea, is dopamine agonists, specifically bromocriptine and carbergoline.