Finally, an assessment by the Institute of Medicine (IOM) in 2008 (books.nap.edu/openbook.php?record_id=11955) of randomized, controlled trials of medications for PTSD concluded that no drugs have adequate data showing efficacy, including SSRIs, the [alpha]-adrenergic blocker prazosin, anticonvulsants, the atypical antipsychotics olanzapine (Zyprexa) and risperidone (Risperdal), benzodiazepines, the MAO inhibitors phenelzine and brofaromine
(Consonar), other antidepressants, and drugs such as naltrexone or inositol.
versus lithium addition to maportiline: A double-blind study in maprotiline refractory depressed outclients.
perforatum extract Some antidepressants such as inhibits the activity of moclobemide, cimoxatone and monoaminoxidase enzymes, types brofaromine
are monoaminoxidase A and B (Cott, 1997).
For example, moclobemide is a reversible MAOA-specific drug in clinical practice in the UK, whilst brofaromine
, cimoxatone, and toloxatone are similar drugs not yet used clinically.
A double-blind comparative study of brofaromine
and fluvoxamine in outpatients with panic disorder.
Reversible MAO inhibitors include moclobemide, brofaromine
, toloxatone, and befloxatone, all of which are specific for MAO-A.