Used to exterminate rats and mice, the Russian product contains contains Brodifacoum
which is described as a highly lethal 4-hydroxycoumarin vitamin K antagonist anticoagulant poison.
Used baits were blocks (200 g each) of Brodifacoum
or Bromadiolone, anticoagulant products.
Rodents at 14 WAS controlled by Matikus rodenticide (a.i brodifacoum
Unapproved products sold in convenience stores under names like "K2" and "Spice" have been contaminated with brodifacoum
, an anticoagulant commonly used in rat poison formulas.
MONDAY, July 23, 2018 (HealthDay News) -- Users of synthetic marijuana products and health care providers should be aware of the risk of bleeding associated with contamination of synthetic cannabinoid products with brodifacoum
, according to the U.S.
Laboratory criteria * Elevated international normalized ratios (INRs; [greater than or equal to] 2.0) or abnormal coagulation profile (e.g., prothrombin time in absence of INR values) for which there is no other clinical explanation, or * Detection of a long-acting anticoagulant (e.g., brodifacoum
) in blood, serum, plasma, or urine, as determined by reference laboratory testing.
Several of these cases have tested positive for brodifacoum
, a lethal anticoagulant often used as a rodenticide, or rat poison.
Toxicosis with an anticoagulant rodenticide was suspected because its mate had died 1 day earlier from possible brodifacoum
The bait in-take, external and internal pathological symptoms were similar as has been described for warfarin and brodifacoum
. The bleeding period ranged from 8.06 to 12.94 nights with 13% variation in time.
A restricted-use rodenticide, Brodifacoum
25-D Conservation (EPA Registration 5622837), was applied island wide on 2 application dates, 18 Mar and 9 Apr 2016.
Several anticoagulant classes were used: (1) vitamin K antagonists: brodifacoum
(BDF) and warfarin (both from Sigma-Aldrich, St.