brinzolamide


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brinzolamide

 [brin-zo´lah-mīd]
a carbonic anhydrase inhibitor used in treatment of open-angle glaucoma and ocular hypertension.

Azopt

A topical carbonic anhydride inhibitor that reduces intraocular pressure, used in patients with ocular hypertension or open-angle glaucoma.
 
Adverse effects
Blurred vision and bitter, sour or unusual taste (5–10% of patients); less commonly, blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus, rhinitis.

Azopt®

A topical carbonic anhydride inhibitor that decreases intraocular pressure, used in patients with ocular hypertension or open-angle glaucoma.
 
Adverse effects
Blurred vision and bitter, sour or unusual taste (5–10% of patients); less commonly, blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus or rhinitis.

brinzolamide

A carbonic anhydrase inhibitor drug used in the form of eye drops to control GLAUCOMA. A brand name is Azopt.

carbonic anhydrase inhibitors 

Drugs which inhibit the carbonic anhydrase enzyme in the ciliary epithelium of the ciliary body. This enzyme is essential for the formation of aqueous humour; its reduction results in a decrease in intraocular pressure. Those in use are sulfonamide derivatives. They are administered systemically (e.g. acetazolamide) or topically in the treatment of glaucoma. Examples: acetazolamide, brinzolamide, dichlorphenamide, dorzolamide.
References in periodicals archive ?
For the eyes in the study group, treatment was initiated with prostaglandin monotherapy for 12 eyes, prostaglandin and brimonidine for 5 eyes, and prostaglandin and brinzolamide for 5 eyes.
IOP of the OD remained consistently above 50 mmHg with medications provided (i.e., travoprost, timolol, brinzolamide, brimonidine tartrate, and mannitol 20%).
Meanwhile, the findings of Kobayashi and colleagues showed that after a 4-week discontinuation of latanoprost, patients who had remained on beta-blockers and brinzolamide did not have an expected increase of 25-33% of pretreatment IOP, but only a 15.4% of baseline IOP increase.
The second generation of compounds, brinzolamide and dorzolamide, exhibit nanomolar inhibition and show increased water solubility to allow for use as a topical agent, resulting in fewer unwanted side effects.
Comparing diurnal and nocturnal effects of brinzolamide and timolol on intraocular pressure in patients receiving latanoprost monotherapy.
To optimize his medical management, we added ASA 81 mg daily, brinzolamide 1% topical twice daily, ranitidine 300 mg daily, and vitamin D 1000IU daily.
Aung, "Clinical effectiveness of brinzolamide 1%-brimonidine 0.2% fixed combination for primary open-angle glaucoma and ocular hypertension," Clinical Ophthalmology, vol.
Yu, Development of Inclusion Complex of Brinzolamide with hydroxypropyl-b- cyclodextrin, Carbohyd.
(2,4,6) Mechanism Drug Class Preparations of Action Reduction Adrenergic Brimonidine of Aqueous agonists Apraclonidine Inflow [beta]-blockers Non-selective Timolol Levobunolol Carteolol Selective [beta]-blockers Betaxolol Carbonic Systemic anhydrase Acetazolamide inhibitors Methazolamide Dichlorphenamide Topical Dorzolamide Brinzolamide Increase Cholinergics Pilocarpine in Aqueous Increase Carbachol Outflow trabecular outflow Prostaglandins Latanoprost (xalatan) and other lipid Travoprost (travatan) receptor agonists Increase Bimatoprost (lumigan) uveoscleral Unoprostone outflow Table 2: The Demographic Data of the Patients of POAG Selected for the Study Bimatoprost Timolol Maleate No.