brefeldin A


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brefeldin A

A macrocyclic lactone synthesised from palmitic acid by several fungi, which has antiviral activity.
 
Immunology
Brefeldin A inhibits exocytosis and antigen processing for MHC-I-restricted T cell recognition.

Membrane biology
Brefeldin A blocks the movement of proteins from the endoplasmic reticulum to the Golgi system. It is used to study protein kinetics.
References in periodicals archive ?
One of these promising anticancer drugs is Brefeldin A (BFA), a cyclic macrolide with a lactone ring.
The main goal of this research programme is to couple Brefeldin A (BFA) with Aphios' SuperFluids critical fluid nanosomes (SFS-CFN) technology for intravenous administration to achieve and maintain therapeutic plasma concentrations.
Contract awarded for Other reagents, glassware current 61 items buy Brefeldin A