breast cancer resistance protein


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breast cancer resistance protein

A xenobiotic transporter protein encoded by ABCG2 on chromosome 4q22, belonging to the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance, and likely serves as a cellular defence mechanism in response to mitoxantrone and anthracycline (daunorubicin and doxorubicin) exposure. It is highly expressed in the placenta, but its role there is unknown.
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References in periodicals archive ?
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Expression of breast cancer resistance protein in blast cells from patients with acute leukemia.
Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.
The parental cell line was transfected with breast cancer resistance protein (BCRP) cDNA to produce BCRP overexpressing subline, which was maintained with 800ng/ml G418 (Efferth et al.

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