breast cancer resistance protein


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breast cancer resistance protein

A xenobiotic transporter protein encoded by ABCG2 on chromosome 4q22, belonging to the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance, and likely serves as a cellular defence mechanism in response to mitoxantrone and anthracycline (daunorubicin and doxorubicin) exposure. It is highly expressed in the placenta, but its role there is unknown.
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References in periodicals archive ?
Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation.
Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression.
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Mao, "Structure and function of the human breast cancer resistance protein (BCRP/ABCG2)," Current Drug Metabolism, vol.
Simoni et al., "High doses of ursodeoxycholic acid up-regulate the expression of placental breast cancer resistance protein in patients affected by intrahepatic cholestasis of pregnancy," PLoS ONE, vol.
Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
Expression of breast cancer resistance protein in blast cells from patients with acute leukemia.
Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.
Abbreviations: EGCG, (-)-Epigallocatechin-3-gallate; MCF-7Tam, MCF-7 resistant to tamoxifen; MRP1, Multidrug Resistance Protein 1: P-gp, Glycoprotein P; BCRP, Breast Cancer Resistance Proteins; ER[alpha], Estrogen Receptor alpha
Abbreviations: BCRP, breast cancer resistance protein; FCM, flow cytometry: FTC, Fumitremorgin C; MDR, multidrug resistance; MTT, 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyl tetrazolium bromide; P-gp, P-glycoprotein

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