BRCA2

(redirected from breast cancer 2, early onset)

BRCA2

A gene on chromosome 13q12.3 that encodes a protein which, like BRCA1, is involved in maintenance of genome stability, especially the homologous recombination pathway for double-stranded DNA repair; like BRCA1, it carries a marked increase in the lifetime risk of breast and ovarian cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

BRCA2

Molecular oncology A tumor suppressor gene linked to breast and ovarian CA See Tumor suppressor gene.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
BRCA1 or breast cancer 2, early onset (BRCA2) germline mutation carriers have a high probability (70%80%) of developing breast cancer (69) and a higher risk for ovarian cancer (30%-50%).
Other examples of high-risk features include chest radiation therapy (eg, for Hodgkin's lymphoma) between age 10 to 30 or a breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) mutation carried by the patient or a first-degree family member, which can leave patients more susceptible to breast cancer.
We already use this strategy for a very small segment of the population, those with inherited mutations in the BRCA12 (breast cancer 1, early onset) and BRCA2 (breast cancer 2, early onset) genes.
The Myriad patents involve various aspects of the BRCA1 (2) (breast cancer 1, early onset) and BRCA2 (breast cancer 2, early onset) genes.

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