BRCA2

(redirected from breast cancer 2, early onset)

BRCA2

symbol for a breast cancer gene with activity similar to that of BRCA1.

BRCA2

A gene on chromosome 13q12.3 that encodes a protein which, like BRCA1, is involved in maintenance of genome stability, especially the homologous recombination pathway for double-stranded DNA repair; like BRCA1, it carries a marked increase in the lifetime risk of breast and ovarian cancer.

BRCA2

Molecular oncology A tumor suppressor gene linked to breast and ovarian CA See Tumor suppressor gene.
References in periodicals archive ?
2] Human genes: BRCA1, breast cancer 1, early onset; BRCA2, breast cancer 2, early onset.
BRCA1: breast cancer 1, early onset; BRCA2: breast cancer 2, early onset
Other examples of high-risk features include chest radiation therapy (eg, for Hodgkin's lymphoma) between age 10 to 30 or a breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) mutation carried by the patient or a first-degree family member, which can leave patients more susceptible to breast cancer.

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