breakthrough varicella

breakthrough varicella

mild varicella occurring in a patient who was recently vaccinated.
Mentioned in ?
References in periodicals archive ?
The incidence rate of breakthrough varicella steadily decreased over time and no increase was observed during the 14 years of follow-up.
Breakthrough varicella generally is mild and can be difficult to diagnose clinically (8).
Breakthrough Varicella Rose With Time Since Vaccination Year Since Vaccination Cases per 1,000 person-years 1 1.6 5 9.0 8 20.4 9 58.2 Note: Based on data from 11,356 subjects who developed varicella.
Recent data suggest that primary vaccine failure is responsible for more cases of breakthrough varicella than previously realized, Dr.
Considering the cell culture and animal model data for VZV-MSP and the lost B-cell epitope resulting from the D150N gE mutation, this mutation should be monitored to determine whether it plays a role in more severe cases of varicella or zoster or in breakthrough varicella in previously immunized children.
A majority of 610 primary care physicians surveyed before the recommendation for a second dose of varicella vaccine said that the current level of breakthrough varicella disease in their practices was acceptable, Dr.
Risk factors for breakthrough varicella included a history of eczema (3.8 times greater risk), time since vaccination (relative risk 3.0 if vaccinated 5 or more years before the outbreak), and age at vaccination (relative risk 2.6 if vaccinated at age 18 months or less).
The effectiveness (or failure) of Var can be measured by the proportion of vaccinated children who develop varicella breakthrough infections (i.e., cases of varicella that occur following exposure to wild-type virus) > 42 days after Var; each recommended vaccine was compared with the incidence of breakthrough varicella in children who received Var simultaneously with the vaccine, children who received Var [greater than or equal to]30 days after the vaccine, and control children who received Var [greater than or equal to]30 days before or after the vaccine.
At the same time, recent data suggest that primary vaccine failure is responsible for more cases of breakthrough varicella than previously realized, Dr.
In a case-control study of 1,017 immunized children (339 with breakthrough varicella disease), the vaccine's overall effectiveness declined from 97% in the first year after administration to 84% in years 2-8 after vaccination (JAMA 2004;291:851-5).
Breakthrough varicella disease occurred more than 2 weeks following vaccination in 5.6% of 1,042 subjects with verified records, compared with 71.7% of 399 unvaccinated subjects from the same survey.
* Reports of breakthrough varicella will continue to be reported, while a second dose of varicella vaccine will be recommended by the end of 2005.