breakthrough seizure


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Related to breakthrough seizure: epilepsy

breakthrough seizure

A seizure that occurs despite the use of therapeutic concentrations of a previously effective antiepileptic drug.
See also: seizure
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That continuous substitution with different generics isn't such a big deal for a patient using generic Vicodin to treat an achy back; however, for a patient with epilepsy, the frequent variance in potency can mean the difference between a normal, seizure-free life or risking breakthrough seizures, brain damage and even death -- along with all the additional expenses associated with these unfortunate outcomes.
Strategies for management of school, workload, and potential stress, with the goals of maintaining balance and preventing breakthrough seizures, are explored.
The pharmacy benefits manager's analysis stems from questions over the last several years about generic AED drugs, specifically whether there is a higher risk of so-called breakthrough seizures or toxic side effects after patients are switched from a brand-name antiepileptic to a generic version.
I have had repeated personal experience with well-controlled epilepsy patients having breakthrough seizures when they switched from Dilantin to generic phenytoin, and there are published reports of a less anecdotal nature with similar findings.
Although physicians who treat epilepsy patients often express concerns about bioavailability differences between a branded AED and its generic version, which could lead to breakthrough seizures, generic AEDs have an important role in the treatment of epilepsy, and several popular branded second-generation AEDs contend with strong direct generic competition.